ArticleOcular oncology and pathology2021
Distinguishing Choroidal Nevi from Melanomas Using the MOLES Algorithm: Evaluation in an Ocular Nevus Clinic.
Article in Ocular oncology and pathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 24 citations in OpenAlex.
- Age distribution and characteristics of choroidal nevi in 35 559 individuals: A nationwide study using optometry fundus photography.Acta ophthalmologica · 2026Article
- Validation of MOLES score for small choroidal melanomas: impact of assuming enlargement for telemedicine in sizable lesions.Eye (London, England) · 2026Article
- Comparison of MOLES and MelCancers · 2026Article
- Metastatic potential of small posterior uveal melanomas.Acta ophthalmologica · 2026Article
- Artificial Intelligence in Ocular Oncology: Differentiating Choroidal Melanocytic Lesions.Ophthalmology science · 2026Article
- Clinical Applications of Artificial Intelligence in Uveal Melanoma.Anticancer research · 2025Review
- Clinical Applications of Optical Coherence Tomography and Optical Coherence Tomography Angiography in Uveal Melanoma: A Narrative Review.Diagnostics (Basel, Switzerland) · 2025Review
- Artificial intelligence in the diagnosis of uveal melanoma: advances and applications.Experimental biology and medicine (Maywood, N.J.) · 2025Review
- Performance of the MOLES and TFSOM-DIM scores in classifying choroidal nevi and melanoma.Scientific reports · 2024Article
- Real-world experience of implementing the MOLES score in a virtual choroidal naevi clinic at a tertiary referral centre.Eye (London, England) · 2024Article
- Choroidal Nevus Features Associated with Subspecialty Referral.Ophthalmology. Retina · 2023Article
- Is Tumour Thickness Measurement Required for MOLES Scoring of Melanocytic Choroidal Tumours?Ocular oncology and pathology · 2023Article
- Can the MOLES acronym and scoring system improve the management of patients with melanocytic choroidal tumours?Eye (London, England) · 2023Review
- Assessing Choroidal Nevi, Melanomas and Indeterminate Melanocytic Lesions Using Multimodal Imaging-A Retrospective Chart Review.Current oncology (Toronto, Ont.) · 2022Article
- A Word of Caution regarding Risk Factors for Malignant Transformation of Choroidal Nevi.Ocular oncology and pathology · 2021Article
- What's in a Name? Large Choroidal Nevus, Small Choroidal Melanoma, or Indeterminate Melanocytic Tumor.Ocular oncology and pathology · 2021Article
- Article
- Development and Validation of a Deep Learning Algorithm for Differentiation of Choroidal Nevi from Small Melanoma in Fundus Photographs.Ophthalmology scienceArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveThe aim of this study was to determine the sensitivity and specificity of the MOLES scoring system in differentiating choroidal melanomas from nevi according to Mushroom shape, Orange pigment, Large tumor size, Enlarging tumor, and Subretinal fluid (SRF).
methodsColor photographs, fundus-autofluorescence images, and optical coherence tomography of 222 melanocytic choroidal tumors were reviewed. Each MOLES feature was retrospectively scored between 0 and 2 and tumors categorized as "common nevus," "low-risk nevus," "high-risk nevus," and "probable melanoma" according to the total score. MOLES scores were compared with the experts' diagnosis of melanoma.
resultsThe MOLES scoring system indicated melanoma in all 81 tumors diagnosed as such by ocular oncologists (100% sensitivity) and nevus in 135 of 141 tumors given this diagnosis by these experts (95.7% specificity). Of the 6 tumors with discordant diagnoses, 4 had basal diameters exceeding 6 mm, all with SRF and/or orange pigment, and 2 small tumors showed either significant SRF with traces of orange pigment, or vice versa.
conclusionsThe MOLES system for diagnosing melanocytic choroidal tumors compares well with expert diagnosis but needs to be evaluated when deployed by ophthalmologists and community optometrists in a wide variety of working environments.
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