Evidence map›Paper›PMID 34604070›Full record

ArticleFrontiers in oncology2021

Noora Nykänen, Rami Mäkelä, Antti Arjonen, Ville Härmä, Laura Lewandowski, Eileen Snowden, Rainer Blaesius, Ismo Jantunen, Teijo Kuopio, Juha Kononen and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Pan-cancer ex vivo target evaluation of phosphodiesterase 3 A (PDE3A).Journal of molecular medicine (Berlin, Germany) · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Noora NykänenMisvik Biology Oy, Turku, Finland.
Rami MäkeläMisvik Biology Oy, Turku, Finland.
Antti ArjonenMisvik Biology Oy, Turku, Finland.
Ville HärmäMisvik Biology Oy, Turku, Finland.
Laura LewandowskiMisvik Biology Oy, Turku, Finland.
Eileen SnowdenGenomic Sciences, BD Technologies, Research Triangle Park, Durham, NC, United States.
Rainer BlaesiusGenomic Sciences, BD Technologies, Research Triangle Park, Durham, NC, United States.
Ismo JantunenCentral Finland Health Care District, Jyväskylä, Finland.
Teijo KuopioCentral Finland Health Care District, Jyväskylä, Finland.
Juha KononenDocrates Cancer Center, Helsinki, Finland.
Juha K RantalaMisvik Biology Oy, Turku, Finland.
BD Technologie (United States) · USUniversity of Sheffield · GBCentral Finland Health Care District · FIDocrates Cancer Center · FIUniversity of Jyväskylä · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The purpose of

Indexed as

ex vivo drug screeningHER2molecular profilingparotid squamous cell carcinomaprecision oncologyT-DM1trastuzumab

Identifiers

PMID34604070
PMCPMC8481915
OpenAlexW3193716410

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.