ArticleQuantitative imaging in medicine and surgery2021
Concomitant functional impairment and reorganization in the linkage between the cerebellum and default mode network in patients with type 2 diabetes mellitus.
Article in Quantitative imaging in medicine and surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 9 citations in OpenAlex.
- Assessment of cerebrovascular reactivity in middle cerebral artery stenosis using non-hypercapnic resting-state fMRI: a potential biomarker for hemodynamic alterations.BMC medical imaging · 2026Article
- Altered static and dynamic intrinsic brain activity patterns in type 2 diabetic patients.Scientific reports · 2025Article
- Altered brain functional network connectivity and topology in type 2 diabetes mellitus.Frontiers in neuroscience · 2025Article
- The language-related cerebro-cerebellar pathway in humans: a diffusion imaging-based tractographic study.Quantitative imaging in medicine and surgery · 2023Article
- Alteration in topological organization characteristics of gray matter covariance networks in patients with prediabetes.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2022Article
- Clinical and MRI features about two types of silent cerebral small-vessel disease in type-2 diabetes mellitus: a retrospective cross-sectional study in a tertiary hospital.Quantitative imaging in medicine and surgery · 2022Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
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Abstract
backgroundIncreasing evidence shows that the default mode network (DMN) and cerebellum are prone to structural and functional abnormalities in patients with type 2 diabetes mellitus (T2DM). However, the type of change in the functional connection between the DMN and cerebellum is still unknown.
methodsIn this study, seed-based functional connectivity (FC) analysis was used to examine the intrinsic FC of the cerebellum-DMN between healthy controls (HCs) and T2DM patients. Pearson correlation analysis was used to explore the relationship between clinical variables and changes in FC.
resultsCompared with HCs, T2DM patients showed significantly increased FC of the left crus I-left medial superior frontal gyrus, left crus I-right medial superior frontal gyrus, and right crus I-left medial orbitofrontal cortex. Compared with HCs, T2DM patients showed decreased FC of the lobule IX-the right angular gyrus. Moreover, diabetes duration was positively correlated with increased FC of the left crus I-right medial superior frontal gyrus (r=0.438, P=0.007).
conclusionsConcomitant functional impairment and reorganization in the linkage between the cerebellum and DMN in patients with T2DM may be a biomarker of early brain damage that can help us better understand the pathogenesis of cognitive impairment in T2DM.
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