Evidence map›Paper›PMID 34603828›Full record

ArticleACS catalysis2021

Synthesis of γ-Hydroxy-α-amino Acid Derivatives by Enzymatic Tandem Aldol Addition-Transamination Reactions.

Carlos J Moreno, Karel Hernández, Simon J Charnok, Samantha Gittings, Michael Bolte, Jesús Joglar, Jordi Bujons, Teodor Parella, Pere Clapés

Open access · hybridAbstract read
In one paragraph

Article in ACS catalysis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 39 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Carlos J MorenoInstitute for Advanced Chemistry of Catalonia, Department of Biological Chemistry, IQAC-CSIC, Jordi Girona 18-24, Barcelona 08034, Spain.
Karel HernándezInstitute for Advanced Chemistry of Catalonia, Department of Biological Chemistry, IQAC-CSIC, Jordi Girona 18-24, Barcelona 08034, Spain.
Simon J CharnokProzomix Ltd. West End Industrial Estate, Haltwhistle, Northumberland NE49 9HA, U.K.
Samantha GittingsProzomix Ltd. West End Industrial Estate, Haltwhistle, Northumberland NE49 9HA, U.K.
Michael BolteInstitut für Anorganische Chemie, J.-W.-Goethe-Universität, Frankfurt/Main, Germany.ORCID 0000-0001-5296-6251
Jesús JoglarInstitute for Advanced Chemistry of Catalonia, Department of Biological Chemistry, IQAC-CSIC, Jordi Girona 18-24, Barcelona 08034, Spain.
Jordi BujonsInstitute for Advanced Chemistry of Catalonia, Department of Biological Chemistry, IQAC-CSIC, Jordi Girona 18-24, Barcelona 08034, Spain.ORCID 0000-0003-2944-2905
Teodor ParellaServei de Ressonància Magnètica Nuclear, Universitat Autònoma de Barcelona, Bellaterra, Spain.ORCID 0000-0002-1914-2709
Pere ClapésInstitute for Advanced Chemistry of Catalonia, Department of Biological Chemistry, IQAC-CSIC, Jordi Girona 18-24, Barcelona 08034, Spain.ORCID 0000-0001-5541-4794
Institute of Advanced Chemistry of Catalonia · ESProzomix (United Kingdom) · GBGoethe University Frankfurt · DEUniversitat Autònoma de Barcelona · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Three enzymatic routes toward γ-hydroxy-α-amino acids by tandem aldol addition-transamination one-pot two-step reactions are reported. The approaches feature an enantioselective aldol addition of pyruvate to various nonaromatic aldehydes catalyzed by

Identifiers

PMID34603828
PMCPMC8482765
OpenAlexW3141995765

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.