Evidence map›Paper›PMID 34603790›Full record

ArticleJournal of advanced research2021

Innate tumor-targeted nanozyme overcoming tumor hypoxia for cancer theranostic use.

Hanitrarimalala Veroniaina, Zhenghong Wu, Xiaole Qi

Open access · goldAbstract read
In one paragraph

Article in Journal of advanced research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 42 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. TargetedImmunotherapy advances · 2026
    Review
  5. Emerging Nanoplatforms are Effective Against Tumor Hypoxia.International journal of nanomedicine · 2026
    Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Hanitrarimalala VeroniainaKey Laboratory of Modern Chinese Medicines, China Pharmaceutical University, Nanjing 210009, China.
Zhenghong WuKey Laboratory of Modern Chinese Medicines, China Pharmaceutical University, Nanjing 210009, China.
Xiaole QiKey Laboratory of Modern Chinese Medicines, China Pharmaceutical University, Nanjing 210009, China.
China Pharmaceutical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionHypoxic tumor microenvironment (TME) is the major contributor to cancer metastasis, resistance to chemotherapy, and recurrence of tumors. So far, no approved treatment has been available to overcome tumor hypoxia.

objectivesThe present study aimed to relieve tumor hypoxia via a nanozyme theranostic nanomaterial as well as providing magnetic resonance imaging (MRI)-guided therapy.

methodsManganese dioxide (MnO

resultsBeing a TME-responsive nanomaterial, MnO

conclusionsMnO

Indexed as

Manganese CompoundsNeoplasmsHumansOxidesPrecision MedicineTumor HypoxiaTumor MicroenvironmentManganese CompoundsOxidesApoferritinCancer theranosticManganese dioxideNanozymeTumor hypoxia

Identifiers

PMID34603790
PMCPMC8463960
OpenAlexW3129521019

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.