Evidence map›Paper›PMID 34603755›Full record

ArticleSovremennye tekhnologii v meditsine2021

Associations of Toll-like Receptor Gene Polymorphisms with NETosis Activity as Prognostic Criteria for the Severity of Pneumonia.

M A Karnaushkina, A S Guryev, K O Mironov, E A Dunaeva, V I Korchagin, O Yu Bobkova, I S Vasilyeva, D V Kassina, M M Litvinova

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sovremennye tekhnologii v meditsine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Immune cell disorder in viral pneumonia.Journal of translational medicine · 2026
    Review
  2. Observational
  3. Article
  4. [Association of gene polymorphisms ofZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2023
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 4 countries.

M A KarnaushkinaProfessor, Department of Internal Diseases with a Course of Cardiology and Functional Diagnostics named after Academician V.S. Moiseev; Peoples' Friendship University of Russia, 6 Miklukho-Maklaya St., Moscow, 117198, Russia.
A S GuryevSenior Researcher, Research Laboratory; Moscow Regional Research Clinical Institute named after M.F. Vladimirsky, 61/2-1 Schepkina St., Moscow, 129110, Russia.
K O MironovHead of the Research Group for the Development of New Methods for Identifying Genetic Polymorphisms; Central Research Institute of Epidemiology of the Federal Service on Consumer Rights Protection and Human Wellbeing (Rospotrebnadzor), 3а Novogireevskaya St., Moscow, 111123, Russia.
E A DunaevaResearcher, Research Group for the Development of New Methods for Identifying Genetic Polymorphisms; Central Research Institute of Epidemiology of the Federal Service on Consumer Rights Protection and Human Wellbeing (Rospotrebnadzor), 3а Novogireevskaya St., Moscow, 111123, Russia.
V I KorchaginResearcher, Research Group for the Development of New Methods for Identifying Genetic Polymorphisms; Central Research Institute of Epidemiology of the Federal Service on Consumer Rights Protection and Human Wellbeing (Rospotrebnadzor), 3а Novogireevskaya St., Moscow, 111123, Russia.
O Yu BobkovaPhD Student, Department of Hospital Therapy No.2; I.M. Sechenov First Moscow State Medical University (Sechenov University), 8/2 Trubetskaya St., Moscow, 119991, Russia.
I S VasilyevaAssistant, Department of Hospital Therapy No.2; I.M. Sechenov First Moscow State Medical University (Sechenov University), 8/2 Trubetskaya St., Moscow, 119991, Russia.
D V KassinaResearcher, Research Laboratory; Moscow Regional Research Clinical Institute named after M.F. Vladimirsky, 61/2-1 Schepkina St., Moscow, 129110, Russia.
M M LitvinovaAssociate Professor, Department of Medical Genetics; I.M. Sechenov First Moscow State Medical University (Sechenov University), 8/2 Trubetskaya St., Moscow, 119991, Russia; Geneticist, Center for Personalized Medicine; Moscow Clinical Scientific Center named after A.S. Loginov, Moscow Healthcare Department, 86 Shosse Entuziastov, Moscow, 111123, Russia.
Medical Genetics Center · DESechenov University · RUCentral Research Institute of Epidemiology · RUFederal Service for Surveillance on Consumer Rights Protection and Human Wellbeing · RUMoscow Clinical Scientific Center · RUScience Research Laboratory · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MATERIALS AND

methodsThe study included 38 patients with the main diagnosis of community-acquired pneumonia with a severe course. All the patients underwent standard clinical laboratory examinations, computed tomography of the thoracic organs, microbiological examination of blood and tracheobronchial aspirate. The level of neutrophilic extracellular traps (NETs) in blood smears was determined on the 1

resultsThe level of NETs on the 1

conclusionThe obtained data suggest that level of NETs is a marker of the activity of neutrophils which are closely related to the studied genetic polymorphisms, and affects the prognosis of the pneumonia outcome.

Indexed as

Extracellular TrapsGenetic Predisposition to DiseasePneumoniaToll-Like ReceptorsCase-Control StudiesHumansPolymorphism, Single NucleotidePrognosisToll-Like Receptor 1Toll-Like Receptor 2Toll-Like Receptor 4Toll-Like Receptor 1Toll-Like Receptor 2Toll-Like Receptor 4Toll-Like Receptorsgene polymorphismneutrophilic extracellular trapspneumoniaTLR1TLR2TLR4

Identifiers

PMID34603755
PMCPMC8482823
OpenAlexW3175467911

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.