Evidence map›Paper›PMID 34603519›Full record

ArticleExperimental and therapeutic medicine2021

Resolvin D2 suppresses NLRP3 inflammasome by promoting autophagy in macrophages.

Lijun Cao, Yiya Wang, Yina Wang, Feijuan Lv, Lixiu Liu, Zhen Li

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental and therapeutic medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Regulation of alveolar macrophage death in pulmonary fibrosis: a review.Apoptosis : an international journal on programmed cell death · 2023
    Review
  9. Review
  10. NLRP3 inflammasome in neurodegenerative disease.Translational research : the journal of laboratory and clinical medicine · 2023
    Review
  11. Review
  12. Article
  13. Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Lijun CaoDepartment of Anesthesiology, No. 906 Hospital of the Chinese People's Liberation Army Joint Logistic Support Force, Ningbo, Zhejiang 315040, P.R. China.
Yiya WangDepartment of Anesthesiology, No. 906 Hospital of the Chinese People's Liberation Army Joint Logistic Support Force, Ningbo, Zhejiang 315040, P.R. China.
Yina WangDepartment of Emergency, No. 906 Hospital of the Chinese People's Liberation Army Joint Logistic Support Force, Ningbo, Zhejiang 315040, P.R. China.
Feijuan LvDepartment of Endocrinology, No. 906 Hospital of the Chinese People's Liberation Army Joint Logistic Support Force, Ningbo, Zhejiang 315040, P.R. China.
Lixiu LiuDepartment of Emergency, No. 906 Hospital of the Chinese People's Liberation Army Joint Logistic Support Force, Ningbo, Zhejiang 315040, P.R. China.
Zhen LiDepartment of Emergency, No. 906 Hospital of the Chinese People's Liberation Army Joint Logistic Support Force, Ningbo, Zhejiang 315040, P.R. China.
Chinese People's Liberation Army · CNPeople's Liberation Army 401 Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammasome, a multiprotein complex that regulates interleukin (IL)-1β secretion and pyroptosis, participates in numerous inflammatory diseases, including sepsis, atherosclerosis and type-2 diabetes. Investigating the inflammasome regulation is therefore crucial to understand the inflammasome activation and develop treatment for the related diseases. In addition, it remains unknown how the inflammasome is naturally suppressed during the inflammatory process. The present study aimed to investigate the role of resolvin D2 (RvD2), an innate suppressor of inflammation produced from essential ω3-polyunsaturated fatty acids, in the activation of the inflammasome via

Indexed as

inflammasomeinflammationmacrophageNLR family pyrin domain containing 3resolvin D2

Identifiers

PMID34603519
PMCPMC8453332
OpenAlexW3194167867

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.