ArticleFrontiers in genetics2021
A Genetically Informed Longitudinal Study of Loneliness and Dementia Risk in Older Adults.
Article in Frontiers in genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Investigating relationships between loneliness, social isolation and health.Nature communications · 2026Article
- Social Disconnection in the Brain: Loneliness and Age across Networks using Graph Theory.bioRxiv : the preprint server for biology · 2026Article
- Social disconnection in the brain: loneliness and age across networks using graph theory.Oxford open neuroscience · 2026Article
- Do We Become More Lonely With Age? A Coordinated Data Analysis of Nine Longitudinal Studies.Psychological science · 2024Article
- Correlations between Dementia and Loneliness.International journal of molecular sciences · 2023Review
- The Impact of Loneliness and Social Isolation on Cognitive Aging: A Narrative Review.Journal of Alzheimer's disease reports · 2023Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although several studies have shown small longitudinal associations between baseline loneliness and subsequent dementia risk, studies rarely test whether change in loneliness predicts dementia risk. Furthermore, as both increase with advancing age, genetic and environmental selection processes may confound the putative causal association between loneliness and dementia risk. We used a sample of 2,476 individual twins from three longitudinal twin studies of aging in the Swedish Twin Registry to test the hypothesis that greater positive change in loneliness predicts greater dementia risk. We then used a sample of 1,632 pairs of twins to evaluate the hypothesis that effects of change in loneliness on dementia risk would remain after adjusting for effects of genetic and environmental variance. Phenotypic model results suggest that mild levels of baseline loneliness predict greater dementia risk. Contrary to our hypothesis, change in loneliness did not correlate with dementia risk, regardless of whether genetic and environmental selection confounds were taken into account. Worsening loneliness with age may not confer greater dementia risk.
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Registered trials
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