Evidence map›Paper›PMID 34603335›Full record

ArticleFrontiers in immunology2021

NEK7-Mediated Activation of NLRP3 Inflammasome Is Coordinated by Potassium Efflux/Syk/JNK Signaling During

Ruiqing Liu, Yashan Liu, Chang Liu, Aijiao Gao, Lin Wang, Huixin Tang, Qiang Wu, Xia Wang, Derun Tian, Zhi Qi and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
  2. Review
  3. Microbiome dysbiosis and therapeutic restoration in atopic dermatitis.Frontiers in cellular and infection microbiology · 2026
    Review
  4. Article
  5. α-hemolysin polymorphisms in methicillin-resistantbioRxiv : the preprint server for biology · 2025
    Article
  6. Article
  7. NLRP inflammasomes in health and disease.Molecular biomedicine · 2024
    Review
  8. Article
  9. Article
  10. Article
  11. The NLRP3 inflammasome in viral infection (Review).Molecular medicine reports · 2023
    Review
  12. Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Review
  19. The Critical Role of Potassium Efflux and Nek7 inFrontiers in microbiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Ruiqing LiuSchool of Medical Laboratory, Tianjin Medical University, Tianjin, China.
Yashan LiuSchool of Medical Laboratory, Tianjin Medical University, Tianjin, China.
Chang LiuSchool of Medical Laboratory, Tianjin Medical University, Tianjin, China.
Aijiao GaoSchool of Medical Laboratory, Tianjin Medical University, Tianjin, China.
Lin WangSchool of Medical Laboratory, Tianjin Medical University, Tianjin, China.
Huixin TangSchool of Medical Laboratory, Tianjin Medical University, Tianjin, China.
Qiang WuKey Laboratory of Emergency and Trauma, Ministry of Education, College of Emergency and Trauma, Hainan Medical University, Haikou, China.
Xia WangDepartment of Laboratory Medicine, West China Second University Hospital, Sichuan University, Key Laboratory of Birth Defects and Related Diseases Of Women and Children (Sichuan University), Ministry of Education, Chengdu, China.
Derun TianSchool of Medical Laboratory, Tianjin Medical University, Tianjin, China.
Zhi QiDepartment of Molecular Pharmacology, School of Medicine, Nankai University, Tianjin, China.
Yanna ShenSchool of Medical Laboratory, Tianjin Medical University, Tianjin, China.
Tianjin Medical University · CNHainan Medical University · CNNankai University · CNSichuan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsFemaleInflammasomesMAP Kinase Signaling SystemMiceMice, Inbred C57BLNIMA-Related KinasesNLR Family, Pyrin Domain-Containing 3 ProteinPotassiumStaphylococcal InfectionsSyk KinaseInflammasomesNek7 protein, mouseNIMA-Related KinasesNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mousePotassiumSyk KinaseSyk protein, mouseJNKK+ effluxNEK7NLRP3 inflammasomeS. aureusSyk

Identifiers

PMID34603335
PMCPMC8481599
OpenAlexW3199897332

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.