Evidence map›Paper›PMID 34603325›Full record

ArticleFrontiers in immunology2021

Increased Monocyte-Derived CD11b

Steven P Cass, Olivia Mekhael, Danya Thayaparan, Joshua J C McGrath, Spencer D Revill, Matthew F Fantauzzi, Peiyao Wang, Amir Reihani, Aaron I Hayat, Christopher S Stevenson and 4 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 12 citations in OpenAlex.

  1. Murine models of pulmonary fibrosis: mechanisms, limitations and translational insights.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  2. Article
  3. Article
  4. SignallingERJ open research · 2025
    Article
  5. Immunomodulatory effect of propolisOpen veterinary journal · 2024
    Article
  6. Article
  7. Article
  8. Review
  9. Targeting the human βRespirology (Carlton, Vic.) · 2022
    Article
  10. No smoke without fire: the impact of cigarette smoking on the immune control of tuberculosis.European respiratory review : an official journal of the European Respiratory Society · 2022
    Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Steven P CassMedical Sciences Graduate Program, McMaster University, Hamilton, ON, Canada.
Olivia MekhaelMedical Sciences Graduate Program, McMaster University, Hamilton, ON, Canada.
Danya ThayaparanMedical Sciences Graduate Program, McMaster University, Hamilton, ON, Canada.
Joshua J C McGrathMedical Sciences Graduate Program, McMaster University, Hamilton, ON, Canada.
Spencer D RevillMedical Sciences Graduate Program, McMaster University, Hamilton, ON, Canada.
Matthew F FantauzziMedical Sciences Graduate Program, McMaster University, Hamilton, ON, Canada.
Peiyao WangDepartment Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada.
Amir ReihaniDepartment of Medicine, Firestone Institute for Respiratory Health, McMaster University and The Research Institute of St. Joe's Hamilton, Hamilton, ON, Canada.
Aaron I HayatMedical Sciences Graduate Program, McMaster University, Hamilton, ON, Canada.
Christopher S StevensonJanssen Disease Interception Accelerator, Janssen Pharmaceutical Companies of Johnson and Johnson, Raritan, NJ, United States.
Anna Dvorkin-GhevaDepartment of Medicine, McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada.
Fernando M BotelhoDepartment of Medicine, McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada.
Martin R StämpfliDepartment of Medicine, Firestone Institute for Respiratory Health, McMaster University and The Research Institute of St. Joe's Hamilton, Hamilton, ON, Canada.
Kjetil AskDepartment of Medicine, Firestone Institute for Respiratory Health, McMaster University and The Research Institute of St. Joe's Hamilton, Hamilton, ON, Canada.
McMaster University · CAMcMaster University Medical Centre · CAJohnson & Johnson (United States) · USSt. Joseph’s Healthcare Hamilton · CA

Funding

CIHR PJT-159792
6 · The paper itself

Abstract

Rationale: The accumulation of macrophages in the airways and the pulmonary interstitium is a hallmark of cigarette smoke-associated inflammation. Notably, pulmonary macrophages are not a homogenous population but consist of several subpopulations. To date, the manner in which cigarette smoke exposure affects the relative composition and functional capacity of macrophage subpopulations has not been elucidated. Methods: Using a whole-body cigarette smoke exposure system, we investigated the impact of cigarette smoke on macrophage subpopulations in C57BL/6 mice using flow cytometry-based approaches. Moreover, we used bromodeoxyuridine labelling plus Main Results: Cigarette smoke exposure altered the composition of pulmonary macrophages increasing CD11b Conclusion: Cigarette smoke exposure modified the composition of pulmonary macrophage by expanding CD11b

Indexed as

Airway RemodelingAnimalsBleomycinCD11b AntigenCells, CulturedCigarette SmokingDisease Models, AnimalFemaleHumansInterleukin-1alphaInterleukin 1 Receptor Antagonist ProteinLungLung InjuryMacrophagesMiceMice, Inbred C57BLBleomycinCD11b AntigenIL1R1 protein, mouseInterleukin-1alphaInterleukin 1 Receptor Antagonist ProteinReceptors, Interleukin-1 Type Icigarette smoke (CS)fibrogenesisimmunopathologymacrophagetissue remodelling

Identifiers

PMID34603325
PMCPMC8481926
OpenAlexW3200435777

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.