Evidence map›Paper›PMID 34603324›Full record

ReviewFrontiers in immunology2021

Machine Learning Applications in Solid Organ Transplantation and Related Complications.

Jeremy A Balch, Daniel Delitto, Patrick J Tighe, Ali Zarrinpar, Philip A Efron, Parisa Rashidi, Gilbert R Upchurch, Azra Bihorac, Tyler J Loftus

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Article
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  7. Article
  8. Review
  9. Article
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  11. Article
  12. Artificial Intelligence: Present and Future Potential for Solid Organ Transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2022
    Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Jeremy A BalchDepartment of Surgery, University of Florida Health, Gainesville, FL, United States.
Daniel DelittoDepartment of Surgery, Johns Hopkins University, Baltimore, MD, United States.
Patrick J TigheDepartment of Anesthesiology, University of Florida Health, Gainesville, FL, United States.
Ali ZarrinparDepartment of Surgery, University of Florida Health, Gainesville, FL, United States.
Philip A EfronDepartment of Surgery, University of Florida Health, Gainesville, FL, United States.
Parisa RashidiDepartment of Biomedical Engineering, University of Florida, Gainesville, FL, United States.
Gilbert R UpchurchDepartment of Surgery, University of Florida Health, Gainesville, FL, United States.
Azra BihoracPrecision and Intelligent Systems in Medicine (PrismaP), University of Florida, Gainesville, FL, United States.
Tyler J LoftusDepartment of Surgery, University of Florida Health, Gainesville, FL, United States.
University of Florida Health · USUniversity of Florida · USJohns Hopkins University · US

Funding

University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI CHRISTIAAN LEEUWENBURGH · 2007 to 2026
$22.8M
Integrating data, algorithms and clinical reasoning for surgical risk assessmentR01GM110240 · NIGMS · UNIVERSITY OF FLORIDA · PI BIHORAC, AZRA, RASHIDI, PARISA · 2016 to 2025
$5.1M
Finding Good TEMporal PostOperative pain Signatures (TEMPOS)R01GM114290 · NIGMS · UNIVERSITY OF FLORIDA · PI TIGHE, PATRICK J · 2015 to 2019
$2.5M
Aligning Patient Acuity with Intensity of Care after SurgeryK23GM140268 · NIGMS · UNIVERSITY OF FLORIDA · PI LOFTUS, TYLER J · 2020 to 2023
$619k
Autonomous Pain Recognition in Non-Verbal and Critically Ill PatientsR21EB027344 · NIBIB · UNIVERSITY OF FLORIDA · PI RASHIDI, PARISA · 2019 to 2022
$577k
NIA NIH HHS P30 AG028740NIBIB NIH HHS R21 EB027344NIGMS NIH HHS K23 GM140268NIGMS NIH HHS R01 GM110240NIGMS NIH HHS R01 GM114290
6 · The paper itself

Abstract

The complexity of transplant medicine pushes the boundaries of innate, human reasoning. From networks of immune modulators to dynamic pharmacokinetics to variable postoperative graft survival to equitable allocation of scarce organs, machine learning promises to inform clinical decision making by deciphering prodigious amounts of available data. This paper reviews current research describing how algorithms have the potential to augment clinical practice in solid organ transplantation. We provide a general introduction to different machine learning techniques, describing their strengths, limitations, and barriers to clinical implementation. We summarize emerging evidence that recent advances that allow machine learning algorithms to predict acute post-surgical and long-term outcomes, classify biopsy and radiographic data, augment pharmacologic decision making, and accurately represent the complexity of host immune response. Yet, many of these applications exist in pre-clinical form only, supported primarily by evidence of single-center, retrospective studies. Prospective investigation of these technologies has the potential to unlock the potential of machine learning to augment solid organ transplantation clinical care and health care delivery systems.

Indexed as

Machine LearningOrgan TransplantationClinical Decision-MakingData MiningDecision Support TechniquesDiagnosis, Computer-AssistedGraft SurvivalHumansPostoperative ComplicationsPredictive Value of TestsRisk AssessmentRisk FactorsTherapy, Computer-AssistedTime FactorsTreatment Outcomeartificial intelligencecritical caremachine learningorgan allocationtransplantation

Identifiers

PMID34603324
PMCPMC8481939
OpenAlexW3201203768

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.