Evidence map›Paper›PMID 34603316›Full record

SynthesisFrontiers in immunology2021

A Systematic Review of the Tumor-Infiltrating CD8

Mahdi Abdoli Shadbad, Zahra Asadzadeh, Negar Hosseinkhani, Afshin Derakhshani, Nazila Alizadeh, Oronzo Brunetti, Nicola Silvestris, Behzad Baradaran

Open access · goldAbstract readSystematic Review
In one paragraph

Synthesis in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Article
  7. Tumor-infiltrating CD8Heliyon · 2024
    Article
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Mahdi Abdoli ShadbadResearch Center for Evidence-Based Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Zahra AsadzadehImmunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Negar HosseinkhaniImmunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Afshin DerakhshaniLaboratory of Experimental Pharmacology, Istituto Di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Tumori Giovanni Paolo II, Bari, Italy.
Nazila AlizadehImmunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Oronzo BrunettiMedical Oncology Unit, IRCCS Istituto Tumori Giovanni Paolo II, Bari, Italy.
Nicola SilvestrisMedical Oncology Unit, IRCCS Istituto Tumori Giovanni Paolo II, Bari, Italy.
Behzad BaradaranImmunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Tabriz University of Medical Sciences · IRIstituto Tumori Bari · ITIstituti di Ricovero e Cura a Carattere Scientifico · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Based on preclinical findings, programmed death-ligand 1 (PD-L1) can substantially attenuate CD8

Indexed as

Precision MedicineTumor EscapeB7-H1 AntigenBrain NeoplasmsCD8-Positive T-LymphocytesClinical Decision-MakingDrug Resistance, NeoplasmGenomicsGliomaHumansImmune Checkpoint InhibitorsLymphocytes, Tumor-InfiltratingNeoplasm GradingSignal TransductionSingle-Cell AnalysisTumor MicroenvironmentB7-H1 AntigenCD274 protein, humanImmune Checkpoint Inhibitorsgliomaimmune checkpointPD-L1personalized medicinesingle-cell sequencingtumor-infiltrating CD8+ T-cellstumor-infiltrating lymphocytestumor microenvironment

Identifiers

PMID34603316
PMCPMC8486082
OpenAlexW3201065186

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.