Evidence map›Paper›PMID 34603283›Full record

ArticleFrontiers in immunology2021

Long-Term Elevated Inflammatory Protein Levels in Asymptomatic SARS-CoV-2 Infected Individuals.

Liina Tserel, Piia Jõgi, Paul Naaber, Julia Maslovskaja, Annika Häling, Ahto Salumets, Eva Zusinaite, Hiie Soeorg, Freddy Lättekivi, Diana Ingerainen and 6 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Liina TserelMolecular Pathology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.
Piia JõgiChildren's Clinic of Tartu University Hospital, Tartu, Estonia.
Paul NaaberSYNLAB Estonia, Tallinn, Estonia.
Julia MaslovskajaMolecular Pathology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.
Annika HälingMolecular Pathology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.
Ahto SalumetsMolecular Pathology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.
Eva ZusinaiteInstitute of Technology, University of Tartu, Tartu, Estonia.
Hiie SoeorgDepartment of Microbiology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.
Freddy LättekiviDepartment of Pathophysiology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.
Diana IngerainenFamily Doctor Center Järveotsa, Tallinn, Estonia.
Mari SootsFamily Doctor Center Kuressaare, Kuressaare, Estonia.
Karolin ToompereDepartment of Epidemiology and Biostatistics, Institute of Family Medicine and Public Health, University of Tartu, Tartu, Estonia.
Katrin KaarnaClinical Research Centre, Tartu University Hospital, Tartu, Estonia.
Kai KisandMolecular Pathology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.
Irja LutsarDepartment of Microbiology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.
Pärt PetersonMolecular Pathology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.
University of Tartu · EETartu University Hospital · EE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The clinical features of SARS-CoV-2 infection range from asymptomatic to severe disease with life-threatening complications. Understanding the persistence of immune responses in asymptomatic individuals merit special attention because of their importance in controlling the spread of the infections. We here studied the antibody and T cell responses, and a wide range of inflammation markers, in 56 SARS-CoV-2 antibody-positive individuals, identified by a population screen after the first wave of SARS-CoV-2 infection. These, mostly asymptomatic individuals, were reanalyzed 7-8 months after their infection together with 115 age-matched seronegative controls. We found that 7-8 months after the infection their antibodies to SARS-CoV-2 Nucleocapsid (N) protein declined whereas we found no decrease in the antibodies to Spike receptor-binding domain (S-RBD) when compared to the findings at seropositivity identification. In contrast to antibodies to N protein, the antibodies to S-RBD correlated with the viral neutralization capacity and with CD4

Indexed as

Asymptomatic InfectionsAntibodies, NeutralizingAntibodies, ViralCD4 Lymphocyte CountCD4-Positive T-LymphocytesCoronavirus Nucleocapsid ProteinsCOVID-19HumansInflammationInflammation MediatorsInterleukin-18MacrophagesMonocytesOncostatin MPhosphoproteinsProtein DomainsAntibodies, NeutralizingAntibodies, ViralCoronavirus Nucleocapsid ProteinsIL18 protein, humanInflammation MediatorsInterleukin-18nucleocapsid phosphoprotein, SARS-CoV-2Oncostatin MOSM protein, humanPhosphoproteinsS100A12 ProteinS100A12 protein, humanSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2TGFA protein, humanTransforming Growth Factor alphaantibodiesinflammation markersOSMS100A12SARS-CoV-2 infectionT cell response

Identifiers

PMID34603283
PMCPMC8484961
OpenAlexW3199506092

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.