ArticleFrontiers in microbiology2021
Appendectomy Is Associated With Alteration of Human Gut Bacterial and Fungal Communities.
Article in Frontiers in microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07478029 (Impact of Polyethylene Glycol), which is not on this map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Polyethylene Glycol (PEG) Bowel Preparation on Intestinal Microbiota Composition and Diversity in Patients Undergoing Appendectomy
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Appendectomy as part of Ladd's procedure: a systematic review and survey analysis.Pediatric surgery international · 2023Pooled it
- Capsulized Fecal Microbiota Transplantation Induces Remission in Patients with Ulcerative Colitis by Gut Microbial Colonization and Metabolite Regulation.Microbiology spectrum · 2023Trial
- Laparoscopic Ladd surgery in adult with chronic intestinal obstruction due to midgut malrotation.Journal of surgical case reports · 2026Article
- Childhood appendectomy is linked with higher digestive, respiratory, and genitourinary disease risk but lower inflammatory bowel disease risk.Evolution, medicine, and public health · 2026Article
- Appendectomy and colorectal cancer: a mini review from the perspective of gut microbiota and mucosal immunity.Frontiers in cellular and infection microbiology · 2026Review
- Appendicitis.Nature reviews. Disease primers · 2025Review
- Appendectomy and Long-term Colorectal Cancer Incidence, Overall and by Tumor Fusobacterium nucleatum Status.Annals of surgery · 2025Article
- Association Between Allergic Rhinitis and Children With Appendectomy-A Nationwide Population-Based Retrospective Cohort Study.Health science reports · 2025Article
- The association between appendectomy and increased invasion of ascending colon cancer: a retrospective study involving 880 patients.World journal of surgical oncology · 2025Article
- The functional landscape of the appendix microbiome under conditions of health and disease.Gut pathogens · 2025Review
- Exploring the Immunological Role of the Microbial Composition of the Appendix and the Associated Risks of Appendectomies.Journal of personalized medicine · 2025Review
- Review
- The association between history of appendectomy and gut microbiota composition: a follow-up cross-sectional study.Frontiers in microbiology · 2025Article
- Gut microbiota and mycobiota change with feeding duration in mice on a high-fat and high-fructose diet.BMC microbiology · 2024Article
- Investigating the causal relationship between inflammatory bowel disease and simple appendicitis using Mendelian randomization.Scientific reports · 2024Article
- Prior Appendicectomy and Gut Microbiota Re-Establishment in Adults after Bowel Preparation and Colonoscopy.Biomedicines · 2024Article
- Environmental and Microbial Factors in Inflammatory Bowel Disease Model Establishment: A Review Partly through Mendelian Randomization.Gut and liver · 2024Review
- Is there a link between appendicitis and the risk of diverticular disease?: a large German cohort study.International journal of colorectal disease · 2024Article
- MALTectomy and psoriasis risk in women: A prospective study in the French E3N prospective cohort.PloS one · 2024Observational
- Endoscopic retrograde appendicitis therapy in adults with uncomplicated acute appendicitis: a systematic review and meta-analysis.iGIE : innovation, investigation and insights · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent research has revealed the importance of the appendix in regulating the intestinal microbiota and mucosal immunity. However, the changes that occur in human gut microbial communities after appendectomy have never been analyzed. We assessed the alterations in gut bacterial and fungal populations associated with a history of appendectomy. In this cross-sectional study, we investigated the association between appendectomy and the gut microbiome using 16S and ITS2 sequencing on fecal samples from 30 healthy individuals with prior appendectomy (HwA) and 30 healthy individuals without appendectomy (HwoA). Analysis showed that the gut bacterial composition of samples from HwA was less diverse than that of samples from HwoA and had a lower abundance of
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.