ArticleFrontiers in psychiatry2021
Neurodevelopmental Trajectories and Clinical Profiles in a Sample of Children and Adolescents With Early- and Very-Early-Onset Schizophrenia.
Article in Frontiers in psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Clinical features and comorbidity in very early-onset schizophrenia: a systematic review.Frontiers in psychiatry · 2023Pooled it
- The Autism-Psychosis Continuum Conundrum: Exploring the Role of the Endocannabinoid System.International journal of environmental research and public health · 2022Pooled it
- Polygenic profiles in youth with early-onset psychosis and offspring of schizophrenia or bipolar disorder patients.European child & adolescent psychiatry · 2026Article
- Formulation, evaluation, and optimisation of soft chewable lozenges using Box-Behnken design for the treatment of schizophrenia.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Psychotic Spectrum Symptoms in Adults with Autism Spectrum Disorder and in Their First-Degree Relatives.Brain sciences · 2026Article
- A novel sex-specific role for 27-hydroxycholesterol in early-onset schizophrenia.Annals of general psychiatry · 2026Article
- DNA methylation signatures associated with early-onset schizophrenia in Chinese patients.Translational psychiatry · 2026Article
- Dealing with Early-Onset Schizophrenia and the Role of Lurasidone: An Expert Opinion.Current neuropharmacology · 2026Review
- Distinct clinical phenotypes of pediatric Obsessive-Compulsive Disorder with and without neurodevelopmental disorders: evidence for a neurodevelopmental continuum.Journal of neurodevelopmental disorders · 2025Article
- Neurocognitive dysfunctions in childhood-onset schizophrenia: A systematic review.Schizophrenia research. Cognition · 2025Review
- Clinical manifestations of children and adolescents with anxiety disorders with and without specific learning disorders.Annals of general psychiatry · 2025Article
- Presence of Psychotic Spectrum Symptoms Before Age 12 in Schizophrenia Patients: A Retrospective Study on Clinical Implications for Early Detection and Intervention.Brain sciences · 2025Article
- MS analysis of the plasma metabolome reveals major changes of amino acid and energy metabolism for early-onset schizophrenia.American journal of translational research · 2024Article
- Autism Spectrum Disorder and Early Psychosis: a narrative review from a neurodevelopmental perspective.Frontiers in psychiatry · 2024Review
- Autism spectrum disorder, very-early onset schizophrenia, and child disintegrative disorder: the challenge of diagnosis. A case-report study.Frontiers in psychiatry · 2023Article
- Electroconvulsive Therapy Reduces Protein Expression Level of EP300 and Improves Psychiatric Symptoms and Disturbance of Thought in Patients with Schizophrenia.Neuropsychiatric disease and treatment · 2023Article
- Patterns of Care for Adolescent With Schizophrenia: A Delphi-Based Consensus Study.Frontiers in psychiatry · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Schizophrenia before the age of 18 years is usually divided into two categories. Early-onset schizophrenia (EOS) presents between the ages of 13 and 17 years, whereas very-early-onset schizophrenia (VEOS) presents at or before the age of 12 years. Previous studies have found that neurodevelopmental difficulties in social, motor, and linguistic domains are commonly observed in VEOS/EOS patients. Recent research has also shown a high prevalence of neurodevelopmental disorders (e.g., intellectual disability, communication disorders, autism spectrum disorder, neurodevelopmental motor disorders) in VEOS/EOS patients, indicating genetic overlap between these conditions. These findings lend support to the neurodevelopmental continuum model, which holds that childhood neurodevelopmental disorders and difficulties and psychiatric disorders (e.g., schizophrenia) fall on an etiological and neurodevelopmental continuum, and should not be considered discrete entities. Based on this literature, in this study we focused on the overlap between neurodevelopmental disorders and schizophrenia investigating, in a large sample (
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