Evidence map›Paper›PMID 34603018›Full record

ArticleFrontiers in pharmacology2021

Identification of Oleanolic Acid as Allosteric Agonist of Integrin α

Lu Jin, Xiaoyu Han, Xinlei Zhang, Zhimin Zhao, Judith Ulrich, Tatiana Syrovets, Thomas Simmet

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Decrypting Integrins by Mixed-Solvent Molecular Dynamics Simulations.Journal of chemical information and modeling · 2023
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Lu JinInstitute of Pharmacology of Natural Products and Clinical Pharmacology, Ulm University, Ulm, Germany.
Xiaoyu HanSchool of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China.
Xinlei ZhangDepartment of Medicinal Chemistry, School of Pharmacy, Fourth Military Medical University, Xi'an, China.
Zhimin ZhaoSchool of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China.
Judith UlrichInstitute of Pharmacology of Natural Products and Clinical Pharmacology, Ulm University, Ulm, Germany.
Tatiana SyrovetsInstitute of Pharmacology of Natural Products and Clinical Pharmacology, Ulm University, Ulm, Germany.
Thomas SimmetInstitute of Pharmacology of Natural Products and Clinical Pharmacology, Ulm University, Ulm, Germany.
Universität Ulm · DESun Yat-sen University · CNAir Force Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oleanolic acid is a widely distributed natural product, which possesses promising antitumor, antiviral, antihyperlipidemic, and anti-inflammatory activities. A heterodimeric complex formed by integrin α

Indexed as

allosteric agonistfree energy profileintegrin αMmetadynamicsoleanolic acid

Identifiers

PMID34603018
PMCPMC8484648
OpenAlexW3201143693

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.