Evidence map›Paper›PMID 34602969›Full record

ArticleFrontiers in neuroscience2021

Case Report: Coexistence of Alzheimer-Type Neuropathology in Fragile X-Associated Tremor Ataxia Syndrome.

Maria Jimena Salcedo-Arellano, Desiree Sanchez, Jun Yi Wang, Yingratana A McLennan, Courtney Jessica Clark, Pablo Juarez, Andrea Schneider, Flora Tassone, Randi J Hagerman, Verónica Martínez-Cerdeño

Open access · goldAbstract readCase Reports
In one paragraph

Article in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Maria Jimena Salcedo-ArellanoDepartment of Pediatrics, University of California, Davis, Sacramento, CA, United States.
Desiree SanchezDepartment of Pathology and Laboratory Medicine, University of California, Davis, Sacramento, CA, United States.
Jun Yi WangMedical Investigation of Neurodevelopmental Disorders (MIND) Institute, University of California, Davis, Sacramento, CA, United States.
Yingratana A McLennanDepartment of Pediatrics, University of California, Davis, Sacramento, CA, United States.
Courtney Jessica ClarkDepartment of Pediatrics, University of California, Davis, Sacramento, CA, United States.
Pablo JuarezDepartment of Pathology and Laboratory Medicine, University of California, Davis, Sacramento, CA, United States.
Andrea SchneiderDepartment of Pediatrics, University of California, Davis, Sacramento, CA, United States.
Flora TassoneMedical Investigation of Neurodevelopmental Disorders (MIND) Institute, University of California, Davis, Sacramento, CA, United States.
Randi J HagermanDepartment of Pediatrics, University of California, Davis, Sacramento, CA, United States.
Verónica Martínez-CerdeñoDepartment of Pathology and Laboratory Medicine, University of California, Davis, Sacramento, CA, United States.
University of California, Davis · USShriners Hospitals for Children - Northern California · US

Funding

UC Davis Clinical and Translational Science CenterUL1TR001860 · NCATS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KENYON, NICHOLAS J., LYLES, COURTNEY REES · 2016 to 2025
$47.3M
GENOTYPE/PHENOTYPE RELATIONSHIPS IN FRAGILE X FAMILIESR01HD036071 · NICHD · UNIVERSITY OF CALIFORNIA DAVIS · PI PAUL J HAGERMAN, RANDI J. HAGERMAN · 1998 to 2026
$13.8M
UC Davis CTSC TL1 Administrative Supplement to Recognize Excellence in Diversity, Equity, Inclusion, and Accessibility MentorshipTL1TR001861 · NCATS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MEDICI, VALENTINA · 2016 to 2025
$4.7M
Fragile X-associated tremor/ataxia syndrome (FXTAS) pathology and anatomy: imaging and clinical correlatesR01NS107131 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MARTINEZ-CERDENO, VERONICA · 2018 to 2022
$2.6M
NCATS NIH HHS TL1 TR001861NCATS NIH HHS UL1 TR001860NICHD NIH HHS R01 HD036071NINDS NIH HHS R01 NS107131
6 · The paper itself

Abstract

This case documents the co-occurrence of the fragile X-associated tremor ataxia syndrome (FXTAS) and Alzheimer-type neuropathology in a 71-year-old premutation carrier with 85 CGG repeats in the fragile X mental retardation 1 (

Indexed as

Alzheimer-type dementiaAPOE ε4 alleleCGG expansioncognitive declineFMR1 geneFXTASneurodegeneration

Identifiers

PMID34602969
PMCPMC8485779
OpenAlexW3201373770

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.