Evidence map›Paper›PMID 34602929›Full record

ArticleEXCLI journal2021

5,6,7,4'-Tetramethoxyflavanone attenuates NADPH oxidase 1/4 and promotes sirtuin-1 to inhibit cell stress, senescence and apoptosis in Aß25-35-mediated SK-N-SH dysfunction.

Pichaya Jumnongprakhon, Ratchanaporn Chokchaisiri, Sarinthorn Thummayot, Apichart Suksamrarn, Chainarong Tocharus, Jiraporn Tocharus

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EXCLI journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Pichaya JumnongprakhonDepartment of Anatomy, Faculty of Medical Science, Naresuan University, Phitsanulok, 65000, Thailand.
Ratchanaporn ChokchaisiriDepartment of Chemistry, School of Science, University of Phayao, Phayao, 56000, Thailand.
Sarinthorn ThummayotDivision of Anatomy, School of Medical Sciences, University of Phayao, Phayao, 56000, Thailand.
Apichart SuksamrarnDepartment of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok 10240, Thailand.
Chainarong TocharusDepartment of Anatomy, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.ORCID https://orcid.org/0000-0001-6750-3700
Jiraporn TocharusDepartment of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand; Center for Research and Development of Natural Products for Health, Chiang Mai University, Chiang Mai, 50200, Thailand.
University of Phayao · THChiang Mai University · THNaresuan University · THRamkhamhaeng University · TH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Amyloidogenesis is a fundamental step of amyloid beta (Aβ) generation-induced toxicity that is commonly reported to disrupt neuronal circuits, function and survival in Alzheimer's disease (AD). The neuroprotective effect of 5,6,7,4'-tetramethoxyflavanone (TMF) from

Indexed as

5,6,7,4'-TetramethoxyflavanoneapoptosisNOX1/4senescence, sirtuin-1

Identifiers

PMID34602929
PMCPMC8481796
OpenAlexW3203520680

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.