Evidence map›Paper›PMID 34602732›Full record

ArticleCanadian journal of veterinary research = Revue canadienne de recherche veterinaire2021

C-kit, flt-3, PDGFR-β, and VEGFR2 expression in canine adrenal tumors and correlation with outcome following adrenalectomy.

Kayla Harding, Carlos H De Mello Souza, Keijiro Shiomitsu, Elizabeth Maxwell, Judit Bertran

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kayla HardingUniversity of Florida College of Veterinary Medicine, 2015 SW 16th Ave, PO Box 100116, Gainesville, Florida 32610, USA.
Carlos H De Mello SouzaUniversity of Florida College of Veterinary Medicine, 2015 SW 16th Ave, PO Box 100116, Gainesville, Florida 32610, USA.
Keijiro ShiomitsuUniversity of Florida College of Veterinary Medicine, 2015 SW 16th Ave, PO Box 100116, Gainesville, Florida 32610, USA.
Elizabeth MaxwellUniversity of Florida College of Veterinary Medicine, 2015 SW 16th Ave, PO Box 100116, Gainesville, Florida 32610, USA.
Judit BertranUniversity of Florida College of Veterinary Medicine, 2015 SW 16th Ave, PO Box 100116, Gainesville, Florida 32610, USA.
Florida College · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The objective of this retrospective study was to evaluate the expression of receptor tyrosine kinases (RTKs) in canine adrenal tumors and correlate this expression with features of tumor aggressiveness and survival in dogs undergoing adrenalectomy. Forty-three canine adrenal tumors were evaluated for expression of c-kit, fms-like tyrosine kinase 3 (flt-3), platelet-derived growth factor receptor-β (PDGFR-β), and vascular endothelial growth factor receptor 2 (VEGFR2) using immunohistochemistry. Tumor RTK staining characteristics were compared to normal adrenals. Medical records were reviewed for data regarding patient outcome and tumor characteristics. Expression of c-kit, flt-3, PDGFR-β, and VEGFR2 was detected in 26.9%, 92.3%, 96.2%, and 61.5% of cortical tumors and 0%, 63.2%, 47.4%, and 15.8% of pheochromocytomas, respectively. Expression of RTKs was not significantly increased when compared to normal adrenals and did not correlate with survival after adrenalectomy. Receptor tyrosine kinases are not overexpressed in canine adrenal tumors compared to normal adrenal tissue. Therapeutic inhibition of these receptors may still represent an effective approach in cases where receptor activation is present.

Indexed as

AdrenalectomyAdrenal Gland NeoplasmsAnimalsBiomarkers, TumorDog DiseasesDogsfms-Like Tyrosine Kinase 3Gene Expression Regulation, NeoplasticImmunohistochemistryProto-Oncogene Proteins c-kitReceptor, Platelet-Derived Growth Factor betaTreatment OutcomeVascular Endothelial Growth Factor Receptor-2Biomarkers, Tumorfms-Like Tyrosine Kinase 3Proto-Oncogene Proteins c-kitReceptor, Platelet-Derived Growth Factor betaVascular Endothelial Growth Factor Receptor-2

Identifiers

PMID34602732
PMCPMC8451711
OpenAlexW3201860569

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.