Evidence map›Paper›PMID 34602608›Full record

ArticleGene therapy2023

Oncolytic Newcastle disease virus expressing the co-stimulator OX40L as immunopotentiator for colorectal cancer therapy.

Limin Tian, Tianyan Liu, Shan Jiang, Yukai Cao, Kai Kang, Han Su, Guiping Ren, Zhenzhong Wang, Wei Xiao, Deshan Li

Abstract read
PubMed Publisher
In one paragraph

Article in Gene therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Current advances in microbial-based cancer therapies.Medical oncology (Northwood, London, England) · 2023
    Review
  14. Review
  15. Article
  16. Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Limin TianCollege of Life Science, Northeast Agricultural University, Harbin, China.
Tianyan LiuJiangsu Kanion Pharmaceutical CO. LTD, State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang, Jiangsu, China.
Shan JiangJiangsu Kanion Pharmaceutical CO. LTD, State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang, Jiangsu, China.
Yukai CaoCollege of Life Science, Northeast Agricultural University, Harbin, China.
Kai KangCollege of Life Science, Northeast Agricultural University, Harbin, China.
Han SuCollege of Life Science, Northeast Agricultural University, Harbin, China.
Guiping RenCollege of Life Science, Northeast Agricultural University, Harbin, China.
Zhenzhong WangJiangsu Kanion Pharmaceutical CO. LTD, State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang, Jiangsu, China.
Wei XiaoJiangsu Kanion Pharmaceutical CO. LTD, State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang, Jiangsu, China. xw_kanion@163.com.
Deshan LiCollege of Life Science, Northeast Agricultural University, Harbin, China. deshanli@163.com.ORCID http://orcid.org/0000-0002-1611-0154
Northeast Agricultural University · CNKanion Pharmaceutical (China) · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

NDV as an attractive candidate for oncolytic immunotherapy selectively lyses tumor cells but shows limited anti-tumor immunity. Immune co-stimulator OX40 ligand (OX40L) boosts anti-tumor immunity response by delivering a potent costimulatory signal to CD4

Indexed as

Colorectal NeoplasmsOncolytic VirusesAdjuvants, ImmunologicAnimalsCD8-Positive T-LymphocytesInterleukin-2MiceNewcastle disease virusOX40 LigandAdjuvants, ImmunologicInterleukin-2OX40 Ligand

Identifiers

PMID34602608
OpenAlexW3201778768

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.