ArticleJournal of atherosclerosis and thrombosis2022
Association between Multimorbidity and Kidney Function among Patients with Non-Dialysis-Dependent CKD: The Fukuoka Kidney Disease Registry Study.
Article in Journal of atherosclerosis and thrombosis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 19 citations in OpenAlex.
- Association between food group intakes and metabolic acidosis in patients with non-dialysis-dependent chronic kidney disease.BMC nephrology · 2026Article
- The diagnostic status of chronic kidney disease in a real-world database in Japan: CHECK-CKD.Clinical and experimental nephrology · 2025Observational
- Association between the urinary sodium-to-potassium ratio and apparent treatment-resistant hypertension in Japanese patients with non-dialysis dependent chronic kidney disease: the Fukuoka Kidney disease Registry study.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Associations of different insulin resistance-related indices with the incidence and progression trajectory of cardiometabolic multimorbidity: a prospective cohort study from UK biobank.Cardiovascular diabetology · 2025Article
- Atherosclerotic Diseases in Chronic Kidney Disease.Journal of atherosclerosis and thrombosis · 2025Review
- Article
- Associations between the Serum Triglyceride Level and Kidney Outcome in Patients with Chronic Kidney Disease: The Fukuoka Kidney disease Registry Study.Journal of atherosclerosis and thrombosis · 2024Article
- Impact of Age on Prescribing Patterns of Cardiovascular Medications in Older Japanese Patients with Non-Dialysis-Dependent Chronic Kidney Disease: A Cross-Sectional Study.Journal of atherosclerosis and thrombosis · 2024Article
- High body mass index and triglyceride levels at health checkups increase the risk of new-onset chronic kidney disease and worsening renal function: the TAMA MED Project-CKD.Clinical and experimental nephrology · 2024Article
- Cardiovascular, renal and mortality risk by the KDIGO heatmap in Japan.Clinical kidney journal · 2024Article
- Relationships of Weight Change from 20 Years of Age with the Risks of All-Cause and Cardiovascular Mortality in Patients with Chronic Kidney Disease.Journal of atherosclerosis and thrombosis · 2024Observational
- Cardiovascular Risk Factor Burden and Treatment Control in Patients with Chronic Kidney Disease: A Cross-Sectional Study.Journal of atherosclerosis and thrombosis · 2023Article
- Multimorbidity prevalence and patterns in chronic kidney disease: findings from an observational multicentre UK cohort study.International urology and nephrology · 2023Article
- The Association of Controlling Nutritional Status Score and Prognostic Nutritional Index with Cardiovascular Diseases: the Fukuoka Kidney Disease Registry Study.Journal of atherosclerosis and thrombosis · 2023Article
- Prevalence, treatment status, and predictors of anemia and erythropoietin hyporesponsiveness in Japanese patients with non-dialysis-dependent chronic kidney disease: a cross-sectional study.Clinical and experimental nephrology · 2022Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimIndividuals with chronic kidney disease (CKD) have a high prevalence of comorbidities, including cardiovascular disease (CVD) and its risk factors. However, epidemiological results to assess the association between multimorbidity and kidney function among the CKD population remains limited.
methodsWe performed a cross-sectional analysis of the association between 23 comorbid conditions and reduced kidney function in 4,476 patients with non-dialysis-dependent CKD enrolled in a multicenter cohort in Japan. Reduced kidney function was defined as an estimated glomerular filtration rate of ≤ 60 mL/min/1.73 m
resultsThe mean age of patients was 67 years (male, 56.0%). The prevalence of hypertension, diabetes mellitus, dyslipidemia, prior CVD, cancer, and bone fracture, which are the major comorbidities, was 83.3%, 28.7%, 45.9%, 23.3%, 12.7%, and 6.3%, respectively. Multivariable-adjusted analyses revealed that age, male sex, hypertension, dyslipidemia, prior CVD, body mass index, urinary protein excretion, and underlying kidney disease were independent factors associated with reduced kidney function. Importantly, the odds ratios (ORs) for reduced kidney function increased linearly as the number of major comorbid conditions increased (OR for 1-2 conditions: 2.22, 95% confidence interval [CI]: 1.65-2.97; OR for 3-4 conditions: 3.04, 95% CI: 2.12-4.37; OR for ≥ 5 conditions: 4.37, 95% CI: 1.75-10.9). The upward trend in OR was more pronounced with cardiovascular comorbidities but not significant with non-cardiovascular comorbidities.
conclusionsIn conclusion, we observed an independent association between cardiovascular comorbidity and its risk factors and reduced kidney function. The results of this study highlight the importance of managing multimorbidity among patients with CKD.
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