Evidence map›Paper›PMID 34602499›Full record

ArticleJournal of Parkinson's disease2022

Axial Impairment Following Deep Brain Stimulation in Parkinson's Disease: A Surgicogenomic Approach.

Naomi P Visanji, Mahdi Ghani, Eric Yu, Erfan Ghani Kakhki, Christine Sato, Danielle Moreno, Taline Naranian, Yu-Yan Poon, Maryam Abdollahi, Maryam Naghibzadeh and 14 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Parkinson's disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06529744 (Improving Prognostic Confidence in Neurodegenerative Diseases Causing Dementia Using Peripheral Biomarkers and Integrative Modeling), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06529744 recruitingnot on this mapstarted 2023, after this paper: background citation

Improving Prognostic Confidence in Neurodegenerative Diseases Causing Dementia Using Peripheral Biomarkers and Integrative Modeling

Typeobservational_patient_registrySponsorUniversity Health Network, TorontoRan2023 to 2027Enrolled500ConditionsDementia, Alzheimer Disease, Dementia With Lewy Bodies, Vascular Dementia
3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Stimulation-Induced Dyskinesia in STN DBS Patients.Movement disorders clinical practice · 2025
    Article
  4. Article
  5. Article
  6. Review
  7. Parkinson's Disease is Predominantly a Genetic Disease.Journal of Parkinson's disease · 2024
    Review
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Naomi P VisanjiEdmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, UHN, Toronto, Ontario, Canada.
Mahdi GhaniDisorDATA Analytics, Ottawa, ON, Canada.
Eric YuThe Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, Quebec, Canada.
Erfan Ghani KakhkiDisorDATA Analytics, Ottawa, ON, Canada.
Christine SatoTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.
Danielle MorenoTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.
Taline NaranianEdmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, UHN, Toronto, Ontario, Canada.
Yu-Yan PoonEdmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, UHN, Toronto, Ontario, Canada.
Maryam AbdollahiEdmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, UHN, Toronto, Ontario, Canada.
Maryam NaghibzadehEdmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, UHN, Toronto, Ontario, Canada.
Rajasumi RajalingamEdmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, UHN, Toronto, Ontario, Canada.
Andres M LozanoDepartment of Neurosurgery, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada.
Suneil K KaliaDepartment of Neurosurgery, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada.
Mojgan HodaieDepartment of Neurosurgery, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada.
Melanie CohnKrembil Brain Institute, Toronto, Ontario, Canada.
Marta StatuckaKrembil Brain Institute, Toronto, Ontario, Canada.
Alexandre BoutetJoint Department of Medical Imaging, University of Toronto, Toronto, Ontario, Canada.
Gavin J B EliasDepartment of Neurosurgery, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada.
Jürgen GermannDepartment of Neurosurgery, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada.
Renato MunhozEdmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, UHN, Toronto, Ontario, Canada.
Anthony E LangEdmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, UHN, Toronto, Ontario, Canada.
Ziv Gan-OrThe Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, Quebec, Canada.
Ekaterina RogaevaTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.
Alfonso FasanoEdmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, UHN, Toronto, Ontario, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPostoperative outcome following deep brain stimulation (DBS) of the subthalamic nucleus is variable, particularly with respect to axial motor improvement. We hypothesized a genetic underpinning to the response to surgical intervention, termed "surgicogenomics".

objectiveWe aimed to identify genetic variants associated with clinical heterogeneity in DBS outcome of Parkinson's disease (PD) patients that could then be applied clinically to target selection leading to improved surgical outcome.

methodsRetrospective clinical data was extracted from 150 patient's charts. Each individual was genotyped using the genome-wide NeuroX array tailored to study neurologic diseases. Genetic data were clustered based on surgical outcome assessed by comparing pre- and post-operative scores of levodopa equivalent daily dose and axial impairment at one and five years post-surgery. Allele frequencies were compared between patients with excellent vs. moderate/poor outcomes grouped using a priori defined cut-offs. We analyzed common variants, burden of rare coding variants, and PD polygenic risk score.

resultsNeuroX identified 2,917 polymorphic markers at 113 genes mapped to known PD loci. The gene-burden analyses of 202 rare nonsynonymous variants suggested a nominal association of axial impairment with 14 genes (most consistent with CRHR1, IP6K2, and PRSS3). The strongest association with surgical outcome was detected between a reduction in levodopa equivalent daily dose and common variations tagging two linkage disequilibrium blocks with SH3GL2.

conclusionOnce validated in independent populations, our findings may be implemented to improve patient selection for DBS in PD.

Indexed as

Deep Brain StimulationParkinson DiseaseHumansLevodopaRetrospective StudiesTreatment OutcomeTrypsinLevodopaPRSS3 protein, humanTrypsindeep brain stimulationgait apraxiagenotypingParkinson’s diseasepostural instability

Identifiers

PMID34602499
PMCPMC8842751

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.