ArticleJournal of Alzheimer's disease : JAD2021
Recurring Gastrointestinal Infections Increase the Risk of Dementia.
Article in Journal of Alzheimer's disease : JAD, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed, 12 citations in OpenAlex.
- Hospital-treated infection associated with Alzheimer's disease pathology: underlying mechanisms.Molecular psychiatry · 2026Review
- Bowel Health, Laxative Use, and Cognitive Function in Older Puerto Rican Adults.Journal of aging research · 2025Article
- Elevated Aβ aggregates in feces from Alzheimer's disease patients: a proof-of-concept study.Alzheimer's research & therapy · 2024Article
- Modulating microbiome-immune axis in the deployment-related chronic diseases of Veterans: report of an expert meeting.Gut microbes · 2023Article
- Hospital-Diagnosed Infections, Autoimmune Diseases, and Subsequent Dementia Incidence.JAMA network open · 2023Article
- Gut microbiome-mediated regulation of neuroinflammation.Current opinion in immunology · 2022Review
- Risk of Alzheimer's Disease Following Influenza Vaccination: A Claims-Based Cohort Study Using Propensity Score Matching.Journal of Alzheimer's disease : JAD · 2022Article
- Research trend of microbiota-gut-brain axis in Alzheimer's disease based on CiteSpace (2012-2021): A bibliometrics analysis of 608 articles.Frontiers in aging neuroscience · 2022Article
- The emerging role of the microbiome in Alzheimer's disease.International review of neurobiology · 2022Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGastrointestinal infections cause significant health problems, including those affecting the immune, musculoskeletal, and nervous system, and are one of the leading causes for death worldwide. Recent findings suggest that microbiota of the gastrointestinal tract contribute to dementia.
objectiveIn this nested case-control study we investigated the role of common gastrointestinal infections on the subsequent risk of dementia.
methodsWe used a longitudinal sample of 202,806 individuals from health claims data of the largest German health insurer and applied a nested case-control design with 23,354 initial dementia cases between 2006 and 2014 and 23,354 matched controls. We used conditional logistic regression to compute odds ratios (ORs) for dementia and corresponding 95%confidence intervals (CIs), adjusting for potential confounders.
resultsThe risk of dementia was increased in patients with recurring incidences of quarters with diagnosed gastrointestinal infections when compared to the unexposed population (one quarter: OR = 1.49, 95%CI = 1.40-1.58; two quarters: OR = 1.70, 95%CI = 1.51-1.91; three or more quarters: OR = 1.64, 95%CI = 1.40-1.93), adjusted for potential confounders.
conclusionOur findings suggest that recurring gastrointestinal infections are associated with an increased risk of subsequent dementia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.