Evidence map›Paper›PMID 34602082›Full record

ArticleEuropean journal of medical research2021

A case of Castleman disease with hemophagocytic syndrome derived from HHV8 infection.

Xiao Cui, Yongfeng Wu, Lin Jia, Jing Chang, Chuanyun Li, Caiping Guo, Tong Zhang, Yingmin Ma, Yulin Zhang

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of medical research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiao CuiDepartment of Infectious Diseases, Beijing You An Hospital, Capital Medical University, Beijing Institute of Hepatology, Beijing, 100069, China.
Yongfeng WuDepartment of Infectious Diseases, Beijing You An Hospital, Capital Medical University, Beijing Institute of Hepatology, Beijing, 100069, China.
Lin JiaDepartment of Infectious Diseases, Beijing You An Hospital, Capital Medical University, Beijing Institute of Hepatology, Beijing, 100069, China.
Jing ChangPathology Diagnostic Center, Beijing You An Hospital, Capital Medical University, Beijing, 100069, China.
Chuanyun LiDepartment of Hepatobiliary Surgery and You An Liver Transplant Center, Beijing You An Hospital, Capital Medical University, Beijing, 100069, China.
Caiping GuoDepartment of Infectious Diseases, Beijing You An Hospital, Capital Medical University, Beijing Institute of Hepatology, Beijing, 100069, China.
Tong ZhangDepartment of Infectious Diseases, Beijing You An Hospital, Capital Medical University, Beijing Institute of Hepatology, Beijing, 100069, China.
Yingmin MaDepartment of Respiratory and Infectious Diseases, Beijing You An Hospital, Capital Medical University, Beijing Institute of Hepatology, Beijing, 100069, China.
Yulin ZhangDepartment of Respiratory and Infectious Diseases, Beijing You An Hospital, Capital Medical University, Beijing Institute of Hepatology, Beijing, 100069, China. yulinzhang@ccmu.edu.cn.ORCID http://orcid.org/0000-0002-1214-594X

Funding

beijing fengtai health system research project 2018-63national natural science foundation of china 81672026national natural science foundation of china 81873761national science and technology major special program of the 13th five-year plan of china 2018ZX10302104national science and technology major special program of the 13th five-year plan of china 2018ZX10302205-002-002youan foundation of liver disease and aids YNKTTS20180123
6 · The paper itself

Abstract

backgroundFor a patient presenting with fever, multiple lymphadenopathy and splenomegaly, pathogen infection should be preferentially considered, followed by lymphoid malignancies. When traditional laboratory and pathological detection cannot find the pathogenic microorganism, metagenomic sequencing (MGS) which targets the person's genome for exceptional genetic disorders may detect a rare pathogen. CASE PRESENTATION: Here, we introduced the diagnostic clue of a case of multicentric Castleman disease (MCD) with hemophagocytic syndrome which was elicited from the detection of human herpesvirus-8 in the blood of a HIV-1 infected person by MGS technology during pathogen inspection. This case highlights the need to increase the awareness of MCD among clinicians and pathologists.

conclusionsMGS technology may play a pivotal role in providing diagnostic clues during pathogen inspection, especially when pathogens are not detectable by conventional methods.

Indexed as

Castleman DiseaseHerpesviridae InfectionsHerpesvirus 8, HumanHumansLymphohistiocytosis, HemophagocyticMaleMiddle AgedPrognosisHemophagocytic syndromeHuman herpes virus-8Metagenomic sequencing technologyMulticentric Castleman disease

Identifiers

PMID34602082
PMCPMC8489086

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.