Evidence map›Paper›PMID 34601991›Full record

ArticleAnnals of medicine2021

Myelin-associated proteins are potential diagnostic markers in patients with primary brain tumour.

Olga M Koper-Lenkiewicz, Anna J Milewska, Joanna Kamińska, Karol Sawicki, Robert Chrzanowski, Justyna Zińczuk, Joanna Reszeć, Marzena Tylicka, Ewa Matuszczak, Joanna Matowicka-Karna and 4 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Review
  2. Siglecs: From Biomodulation to Immunotherapy.Current protein & peptide science · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 3 countries.

Olga M Koper-LenkiewiczDepartment of Clinical Laboratory Diagnostics, Medical University of Bialystok, Białystok, Poland.ORCID 0000-0001-5199-2773
Anna J MilewskaDepartment of Statistics and Medical Informatics, Medical University of Bialystok, Białystok, Poland.
Joanna KamińskaDepartment of Clinical Laboratory Diagnostics, Medical University of Bialystok, Białystok, Poland.ORCID 0000-0002-2986-4852
Karol SawickiDepartment of Neurosurgery, Medical University of Bialystok, Białystok, Poland.ORCID 0000-0001-7127-850X
Robert ChrzanowskiDepartment of Neurosurgery, Medical University of Bialystok, Białystok, Poland.ORCID 0000-0002-2883-394X
Justyna ZińczukDepartment of Clinical Laboratory Diagnostics, Medical University of Bialystok, Białystok, Poland.ORCID 0000-0003-2391-3307
Joanna ReszećDepartment of Medical Pathomorphology, Medical University of Bialystok, Białystok, Poland.ORCID 0000-0002-0169-0897
Marzena TylickaDepartment of Biophysics, Medical University of Białystok, Białystok, Poland.ORCID 0000-0002-9594-8173
Ewa MatuszczakDepartment of Pediatric Surgery, Medical University of Białystok, Białystok, Poland.ORCID 0000-0003-2425-9589
Joanna Matowicka-KarnaDepartment of Clinical Laboratory Diagnostics, Medical University of Bialystok, Białystok, Poland.ORCID 0000-0003-4438-9110
Zenon MariakDepartment of Neurosurgery, Medical University of Bialystok, Białystok, Poland.
Mariusz W MuchaInstitute of Biomedical and Clinical Science, Hatherly Laboratories, University of Exeter Medical School, Exeter, UK.ORCID 0000-0001-5273-1647
Robert PawlakInstitute of Biomedical and Clinical Science, Hatherly Laboratories, University of Exeter Medical School, Exeter, UK.
Violetta Dymicka-PiekarskaDepartment of Clinical Laboratory Diagnostics, Medical University of Bialystok, Białystok, Poland.ORCID 0000-0003-4170-0997
Medical University of Białystok · PLUniversity of Exeter · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionTaking into account the possibility of myelin-associated proteins having a role in brain tumour development, the study aimed to evaluate the diagnostic usefulness of myelin-associated proteins (Nogo-A, MAG, OMgp) released into extracellular space in patients with brain tumours. PATIENTS AND

methodsProtein concentration in primary brain tumour (

resultsThe receiver operator characteristic curve analysis showed that CSF Nogo-A and serum MAG were useful in differentiating patients with primary brain tumour from non-tumoural individuals. This was also true in the case of the separate analysis of the astrocytic tumour versus non-tumoural groups and the meningeal tumour versus non-tumoural groups. Neither Nogo-A nor MAG or OMgp concentrations were significantly different, in serum or CSF, between

conclusionsOur results indicated the potential usefulness of CSF Nogo-A and serum MAG evaluation as circulating biomarkers of primary brain tumours. Because blood is relatively easy to obtain, future research should be conducted to explicitly indicate the value of serum MAG concentration evaluation as a brain tumour biomarker.Key messagesMyelin-associated proteins may be circulating brain tumour biomarkers.Nogo-A and MAG proteins seem to be the most useful in brain tumour diagnosis.Decreased CSF Nogo-A concentration is an adverse prognostic factor for patients' survival.

Indexed as

AdultAgedAged, 80 and overBiomarkers, TumorBrain NeoplasmsCase-Control StudiesFemaleGPI-Linked ProteinsHumansMaleMiddle AgedMyelin-Associated GlycoproteinMyelin ProteinsMyelin SheathNogo ProteinsReceptors, Cell SurfaceBiomarkers, TumorGPI-Linked ProteinsMAG protein, humanMyelin-Associated GlycoproteinMyelin ProteinsNogo ProteinsOMG protein, humanReceptors, Cell SurfaceBiomarkercerebrospinal fluidmyelin-associated proteinsprimary brain tumour

Identifiers

PMID34601991
PMCPMC8491661
OpenAlexW3202087773

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.