ArticleLupus2021
Neuropsychiatric involvement in juvenile-onset systemic lupus erythematosus: Data from the UK Juvenile-onset systemic lupus erythematosus cohort study.
Article in Lupus, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- Neuropsychiatric SLE in children with childhood-onset lupus nephritis: a 20-year retrospective cohort study.Pediatric nephrology (Berlin, Germany) · 2026Article
- Assessment of the prevalence of neurological involvement in a pediatric cohort of children with lupus nephritis: retrospective multicenter study.Pediatric nephrology (Berlin, Germany) · 2026Article
- Efficacy of belimumab in children with systemic lupus erythematosus.BMC pediatrics · 2026Observational
- Clinical Features and Outcome of Neuropsychiatric Manifestations in Juvenile Onset Systemic Lupus Erythematosus.Indian journal of pediatrics · 2026Article
- Beyond the Kidneys: Unmasking Neuropsychiatric Lupus in South Asian Children.Indian journal of pediatrics · 2026Article
- Neurophysiological Testing is Useful for the Diagnosis and Treatment of Neuropsychiatric Systemic Lupus Erythematosus.Case reports in pediatrics · 2026Article
- Neuropsychiatric Systemic Lupus Erythematosus in Children: A Scoping Review.Open access rheumatology : research and reviews · 2026Review
- Biomarkers in Pediatric Neuropsychiatric Systemic Lupus Erythematosus: A Systematic Review.Life (Basel, Switzerland) · 2025Review
- Headaches in juvenile systemic lupus erythematosus patients: a cross-sectional study.Arquivos de neuro-psiquiatria · 2025Article
- Article
- Recent advances in the diagnosis and management of neuropsychiatric lupus.Nature reviews. Rheumatology · 2024Review
- Epstein-Barr Virus encephalitis associated hemophagocytic lymphohistiocytosis in childhood-onset systemic lupus erythematosus: a case-based review.Pediatric rheumatology online journal · 2024Review
- Active implementation of low disease activity state as a treatment endpoint in childhood-onset systemic lupus erythematosus in routine practice is both feasible and associated with better outcomes.Clinical rheumatology · 2024Article
- Diagnosis and Management of Pediatric Neuropsychiatric Systemic Lupus Erythematosus: An Update.Paediatric drugs · 2024Review
- Aseptic Meningitis and White Matter Disease in Childhood-Onset Neuropsychiatric Lupus.Case reports in rheumatology · 2024Article
- Neuropsychiatric involvement in juvenile-onset systemic lupus erythematosus (jSLE).Molecular and cellular pediatrics · 2023Review
- Bortezomib is efficacious in the treatment of severe childhood-onset neuropsychiatric systemic lupus erythematosus with psychosis: a case series and mini-review of B-cell immunomodulation in antibody-mediated diseases.Clinical rheumatology · 2023Review
- Anorexia Nervosa in Juvenile Systemic Lupus Erythematosus (SLE): A Causality Dilemma.Children (Basel, Switzerland) · 2023Review
- Juvenile Neuropsychiatric Systemic Lupus Erythematosus: Identification of Novel Central Neuroinflammation Biomarkers.Journal of clinical immunology · 2023Article
- Antipsychotics reduces mortality in patients with neuropsychiatric systemic lupus erythematosus: a retrospective study of psychiatric consultation cases.Frontiers in psychiatry · 2023Article
Corrections and comments
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Authors and funding
27 authors at 20 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionJuvenile-onset systemic lupus erythematosus (JSLE) is a rare autoimmune/inflammatory disease with significant morbidity and mortality. Neuropsychiatric (NP) involvement is a severe complication, encompassing a heterogeneous range of neurological and psychiatric manifestations.
methodsDemographic, clinical, and laboratory features of NP-SLE were assessed in participants of the UK JSLE Cohort Study, and compared to patients in the same cohort without NP manifestations.
resultsA total of 428 JSLE patients were included in this study, 25% of which exhibited NP features, half of them at first visit. Most common neurological symptoms among NP-JSLE patients included headaches (78.5%), mood disorders (48.6%), cognitive impairment (42%), anxiety (23.3%), seizures (19.6%), movement disorders (17.7%), and cerebrovascular disease (14.9%). Peripheral nervous system involvement was recorded in 7% of NP-SLE patients. NP-JSLE patients more frequently exhibited thrombocytopenia (<100 × 10
conclusionsA significant proportion of JSLE patients experience NP involvement (25%). Juvenile-onset NP-SLE most commonly affects the CNS and is associated with increased overall disease activity and damage.
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