ReviewHypertension (Dallas, Tex. : 1979)2021
Circadian Rhythm, Clock Genes, and Hypertension: Recent Advances in Hypertension.
Review in Hypertension (Dallas, Tex. : 1979), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
79 citing papers in PubMed, 3 syntheses or guidelines pooled it, 122 citations in OpenAlex.
- Chronotherapy for Hypertension: A Meta-Analysis and Systematic Review of RCTs.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2025Pooled it
- The research progress and prospects of circadian rhythm in obesity: a bibliometric analysis.Frontiers in nutrition · 2024Pooled it
- The Association Between Season and Hypertensive Disorders in Pregnancy: a Systematic Review and Meta-analysis.Reproductive sciences (Thousand Oaks, Calif.) · 2023Pooled it
- Tirzepatide and blood pressure reduction: stratified analyses of the SURMOUNT-1 randomised controlled trial.Heart (British Cardiac Society) · 2024Trial
- Molecular and Cellular Underpinnings of Primary Hypertension: An Integrative Mechanistic Framework.Journal of cellular physiology · 2026Review
- Genetic evidence linking circadian rhythm genes and hypertension: A two-sample Mendelian randomization study.The Journal of international medical research · 2026Article
- The Interactions Between Circadian Rhythm, Gut Microbiota, and Anxiety: From Mechanisms to Intervention Strategies.Nutrients · 2026Review
- Managing maternity: Moving care, not patients, using artificial intelligence (AI), internet-of-things (IOT) and point-of-care testing (POCT) devices.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026Article
- Association of Rest-Activity Rhythm and Sleep Regularity With Cardiometabolic Disease in the CARDIA Study.Journal of the American Heart Association · 2026Article
- Liver clock: Malalignment and entrainment therapeutics.World journal of gastrointestinal pharmacology and therapeutics · 2026Review
- Prenatal Exposure to Artificial Light at Night and the Offspring's First 1000-Day Growth: A Prospective Metabolomic and Gene-Environment Interaction Study.Environmental science & technology · 2026Article
- Association of diurnal blood pressure patterns with heart rate variability and retinopathy in patients with essential hypertension.Scientific reports · 2026Article
- Melatonin: a promising therapy to combat type 2 airway inflammation via MT1-Sirt1 pathway.Frontiers in pharmacology · 2026Article
- Dual roles of circadian clock proteins in development and adult homeostasis.Npj biological timing and sleep · 2026Review
- The Link Between Sleep Health Dimensions and Hypertension for Cardiovascular Health.Current epidemiology reports · 2026Review
- Review
- Association of circadian rhythms, MTNR1B, BMAL1, BMAL2, and CRY2 gene polymorphisms and their interactions with type 2 diabetes in coal miners.Frontiers in endocrinology · 2026Article
- Synchronizing immunity with time: unlocking the potential of chrono-immunotherapy in cancer.Frontiers in immunology · 2026Review
- Impact of renal denervation on circadian variations of blood pressure and clock gene expression in spontaneously hypertensive rats.Frontiers in cardiovascular medicine · 2026Article
- Clock genes in pancreatic disease progression: from circadian regulation to dysfunction.Annals of medicine · 2025Review
19 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Accumulating evidence suggests that the molecular circadian clock is crucial in blood pressure (BP) control. Circadian rhythms are controlled by the central clock, which resides in the suprachiasmatic nucleus of the hypothalamus and peripheral clocks throughout the body. Both light and food cues entrain these clocks but whether these cues are important for the circadian rhythm of BP is a growing area of interest. The peripheral clocks in the smooth muscle, perivascular adipose tissue, liver, adrenal gland, and kidney have been recently implicated in the regulation of BP rhythm. Dysregulation of the circadian rhythm of BP is associated with adverse cardiorenal outcomes and increased risk of cardiovascular mortality. In this review, we summarize the most recent advances in peripheral clocks as BP regulators, highlight the adverse outcomes of disrupted circadian BP rhythm in hypertension, and provide insight into potential future work in areas exploring the circadian clock in BP control and chronotherapy. A better understanding of peripheral clock function in regulating the circadian rhythm of BP will help pave the way for targeted therapeutics in the treatment of circadian BP dysregulation and hypertension.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.