ReviewHypertension (Dallas, Tex. : 1979)2021
Hypertension in Diabetes: An Update of Basic Mechanisms and Clinical Disease.
Review in Hypertension (Dallas, Tex. : 1979), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 237 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
237 citing papers in PubMed, 7 syntheses or guidelines pooled it, 384 citations in OpenAlex.
- Blood pressure targets for hypertension in people with diabetes mellitus.The Cochrane database of systematic reviews · 2026Pooled it
- Efficacy and safety of lorundrostat in uncontrolled hypertension: A GRADE-assessed systematic review and meta-analysis of randomized controlled trials.Naunyn-Schmiedeberg's archives of pharmacology · 2026Pooled it
- Optimal dose and effectiveness of different types of physical activity to improve blood pressure in people with type 2 diabetes mellitus: A systematic review and network meta-analysis.Reviews in endocrine & metabolic disorders · 2026Pooled it
- Sublingual varices as predictor of factors associated with cardiovascular diseases: A systematic review with meta-analysis.Oral and maxillofacial surgery · 2024Pooled it
- Influencing factors of stroke in patients with type 2 diabetes: A systematic review and meta-analysis.PloS one · 2024Pooled it
- Pooled it
- Exploring the Causality of Type 1 Diabetes and Stroke Risk: A Mendelian Randomization Study and Meta-analysis.Molecular neurobiology · 2023Pooled it
- Association of hypertension specialist treatment with blood pressure control in Japanese primary care: The J-DOME study.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- pFIB scores for paediatric MASLD fibrosis are associated with risk of youth-onset type 2 diabetes in children with obesity.Diabetologia · 2026Article
- Article
- Effects of combined exercise training with or without nutritional counseling on cardiovascular risk factors in older adults with hypertension: a pragmatic randomized trial.Journal of human hypertension · 2026Article
- Blood Pressure Phenotypes in Patients Recently Diagnosed With Type 2 Diabetes Mellitus and Matched Controls: A Study in Urban Mozambique.Journal of clinical hypertension (Greenwich, Conn.) · 2026Article
- Assessment of Glycemic Control Among Prospective Hajj Pilgrims With Type 2 Diabetes Mellitus in Tangerang City, Indonesia.Journal of the ASEAN Federation of Endocrine Societies · 2026Article
- Reply to: "Beyond BMI in interpreting sex-specific blood pressure trajectories: a comment on Kawasoe et al." [1].Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Beyond BMI in interpreting sex-specific blood pressure trajectories: a comment on Kawasoe et al.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Association between the cumulative average triglyceride glucose-BMI and hypertension incidence among the middle-aged and older population: a prospective nationwide cohort study in China.Journal of hypertension · 2026Article
- Associations of metabolic score for insulin resistance and new-onset stroke in middle-aged and older adults: a national cohort study.Cardiovascular diabetology · 2026Article
- Dose-dependent effects of SGLT2 inhibitors on circadian blood pressure in hypertensive patients with diabetes: A systematic review and Bayesian network meta-analysis.International journal of cardiology. Cardiovascular risk and prevention · 2026Review
- Review
- Sedentary Behavior, Physical Activity, and Hypertension: Genetic Liability and the Role of Metabolic Factors.Clinical cardiology · 2026Article
177 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Epidemiological studies have documented that insulin resistance and diabetes not only constitute metabolic abnormalities but also predispose to hypertension, vascular stiffness, and associated cardiovascular disease. Meanwhile, excessive arterial stiffness and impaired vasorelaxation, in turn, contribute to worsening insulin resistance and the development of diabetes. Molecular mechanisms promoting hypertension in diabetes include inappropriate activation of the renin-angiotensin-aldosterone system and sympathetic nervous system, mitochondria dysfunction, excessive oxidative stress, and systemic inflammation. This review highlights recent studies which have uncovered new underlying mechanisms for the increased propensity for the development of hypertension in association with diabetes. These include enhanced activation of epithelial sodium channels, alterations in extracellular vesicles and their microRNAs, abnormal gut microbiota, and increased renal sodium-glucose cotransporter activity, which collectively predispose to hypertension in association with diabetes. This review also covers socioeconomic factors and currently recommended blood pressure targets and related treatment strategies in diabetic patients with hypertension.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.