Evidence map›Paper›PMID 34601711›Full record

ArticleEuropean geriatric medicine2022

Thyroid stimulating hormone levels and geriatric syndromes: secondary nested case-control study of the Mexican Health and Aging Study.

Mario U Perez-Zepeda, Paloma Almeda-Valdes, Julio Manuel Fernandez-Villa, Ronald C Gomez-Arteaga, Miguel G Borda, Matteo Cesari

Open access · greenAbstract read
In one paragraph

Article in European geriatric medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Aging under endocrine hormone regulation.Frontiers in endocrinology · 2023
    Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 6 institutions in 5 countries.

Mario U Perez-ZepedaResearch Department, INGER Instituto Nacional de Geriatria, Mexico City, Mexico.
Paloma Almeda-ValdesResearch Center of Metabolic Diseases, Instituto Nacional de Ciencias Medicas Y Nutricion Salvador Zubiran, Mexico City, Mexico.
Julio Manuel Fernandez-VillaRed Tematica de Envejecimiento Salud y Desarrollo Social, CONACyT, Mexico City, Mexico. fervilnut@icloud.com.ORCID 0000-0002-5802-2494
Ronald C Gomez-ArteagaClinica del Country-Hospital Universitario San Ignacio, Bogota, Colombia.
Miguel G BordaSemillero de Neurociencias y Envejecimiento, Instituto de Envejecimiento, Facultad de Medicina, Pontificia Universidad Javeriana, Bogota, Colombia.
Matteo CesariGeriatric Unit, IRCCS Istituti Clinici Scientifici Maugeri, Milan, Italy.
Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable · ESHospital Universitario San Ignacio · COInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán · MXIstituti Clinici Scientifici Maugeri · ITPontificia Universidad Javeriana · COUniversidad Anáhuac · MX

Funding

The Mexican Health and Aging Study - IIR01AG018016 · NIA · UNIVERSITY OF TEXAS MED BR GALVESTON · PI Rebeca Wong · 1999 to 2026
$22.6M
NIA NIH HHS R01 AG018016
6 · The paper itself

Abstract

purposeTo determine the incidence of geriatric syndromes (GS) in community dwelling older adults with subclinical hypothyroidism.

methodsThis is an analysis from the Mexican Health and Aging Study, of a subsample of 2089 subjects with TSH determination. From this last subsample, we included 1628 individuals with TSH levels in the subclinical range (4.5-10 µU/ml).

resultsThe multivariate analysis showed that when comparing data obtained from the 2012 wave with the 2015 wave results, there was a significant incidence of some GS such as falls (OR 1.79, CI 1.16-2.77, p = 0.0116), fatigue (OR 2.17, CI 1.40-3.38, p = 0.0348) and depression (OR 1.70, CI 1.06-2.71, p = 0.0246) among the subclinical hypothyroidism group.

conclusionThis study showed a greater incidence of GS in subjects 50 years and older with sub-clinical hypothyroidism, when compared to those with normal thyroid function.

Indexed as

HypothyroidismAgedAgingCase-Control StudiesHumansSyndromeThyrotropinThyrotropinAgingChronic diseaseGeriatric syndromesSubclinical hypothyroidismThyroid stimulating hormone

Identifiers

PMID34601711
PMCPMC8863630
OpenAlexW3203009516

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.