Evidence map›Paper›PMID 34601669›Full record

ArticleUpdates in surgery2022

Is minimally invasive liver surgery a reasonable option in recurrent HCC? A snapshot from the I Go MILS registry.

Giovanni Battista Levi Sandri, Marco Colasanti, Luca Aldrighetti, Alfredo Guglielmi, Umberto Cillo, Vincenzo Mazzaferro, Raffaele Dalla Valle, Luciano De Carlis, Salvatore Gruttadauria, Fabrizio Di Benedetto and 3 more

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In one paragraph

Article in Updates in surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Giovanni Battista Levi SandriDivision of General Surgery and Liver Transplantation, S. Camillo Hospital, Rome, Italy. gblevisandri@gmail.com.ORCID http://orcid.org/0000-0002-7893-5047
Marco ColasantiDivision of General Surgery and Liver Transplantation, S. Camillo Hospital, Rome, Italy.
Luca AldrighettiHepatobiliary Surgery, IRCCS San Raffaele Hospital, Milan, Italy. aldrighetti.luca@hsr.it.
Alfredo GuglielmiDepartment of Hepatobiliary Surgery, G.B. Rossi Hospital, University of Verona, Verona, Italy.
Umberto CilloDepartment of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy.
Vincenzo MazzaferroDepartment of Surgery, HPB Surgery and Liver Transplantation, University of Milan, Milan, Italy.
Raffaele Dalla ValleDepartment of Medicine and Surgery, University of Parma, Parma, Italy.
Luciano De CarlisSurgical and Transplant Department, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
Salvatore GruttadauriaDepartment for the Treatment and Study of Abdominal Diseases and Abdominal Transplantation, Istituto di Ricovero e Cura a Carattere Scientifico-Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione (IRCCS-ISMETT), University of Pittsburgh Medical Center (UPMC), 90127, Palermo, Italy.
Fabrizio Di BenedettoHepato-Pancreato-Biliary Surgery and Liver Transplantation Unit, University of Modena and Reggio Emilia, Modena, Italy.
Alessandro FerreroDepartment of HPB and Digestive Surgery, Ospedale Mauriziano Umberto I, Turin, Italy.
Giuseppe Maria EttorreDivision of General Surgery and Liver Transplantation, S. Camillo Hospital, Rome, Italy.
I Go MILS Group on HCC

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Laparoscopic liver resection (LLR) for Hepatocellular carcinoma (HCC) is a safe procedure. Repeat surgery is more often required, and the role of minimally invasive liver surgery (MILS) is not yet clearly defined. The present study analyzes data compiled by the Italian Group of Minimally Invasive Liver Surgery (IGoMILS) on LLR. To compare repeated LLR with the first LLR for HCC is the primary endpoint. The secondary endpoint was to evaluate the outcome of repeat LLR in the case of primary open versus primary MILS surgery. The data cohort is divided into two groups. Group 1: first liver resection and Group 2: Repeat LLR. To compare the two groups a 3:1 Propensity Score Matching is performed to analyze open versus MILS primary resection. Fifty-two centers were involved in the present study, and 1054 patients were enrolled. 80 patients underwent to a repeat LLR. The type of resection was different, with more major resections in the group 1 before matching the two groups. After propensity score matching 3:1, each group consisted of 222 and 74 patients. No difference between the two groups was observed. In the subgroup analysis, in 44 patients the first resection was performed by an open approach. The other 36 patients were resected with a MILS approach. We found no difference between these two subgroups of patients. The present study in repeat MILS for HCC using the IGoMILS Registry has observed the feasibility and safety of the MILS procedure.

Indexed as

Carcinoma, HepatocellularLaparoscopyLiver NeoplasmsHepatectomyHumansLength of StayPostoperative ComplicationsPropensity ScoreRegistriesRetrospective StudiesIGoMILSLaparoscopic HCCLaparoscopic indicationsLaparoscopic liver resectionMinimally invasiveRecurrenceRedo surgeryRobotic

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.