ArticleThe Journal of nutrition2022
Protein Nutritional Status and Frailty: A Mendelian Randomization Study.
Article in The Journal of nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genetic predisposition to white blood cells in relation to the risk of frailty.Aging clinical and experimental research · 2023Pooled it
- Associations of diet patterns with successful aging, longevity, and extreme longevity: a prospective cohort study among Chinese adults 65 years or older.European journal of nutrition · 2025Article
- Development and validation of a nomogram to predict the risk of post-stroke complex regional pain syndrome.Frontiers in aging neuroscience · 2025Article
- Causal associations between frailty and low back pain: a bidirectional two-sample mendelian randomization study.Aging clinical and experimental research · 2024Article
- Serial gait speed measurements over time and dynamic survival prediction in older adults.The journal of nutrition, health & aging · 2024Article
- Development and Validation of a Nomogram for Predicting Nutritional Risk Based on Frailty Scores in Older Stroke Patients.Aging clinical and experimental research · 2024Article
- Plant-Based Diet Indices and Their Association with Frailty in Older Adults: A CLHLS-Based Cohort Study.Nutrients · 2023Article
- Unraveling the metabolic underpinnings of frailty using multicohort observational and Mendelian randomization analyses.Aging cell · 2023Observational
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Authors and funding
4 authors.
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Abstract
backgroundObservational studies have suggested that better protein nutritional status may contribute to prevention of frailty.
objectiveWe sought to examine this hypothesis using a Mendelian randomization (MR) analysis.
methodsWe conducted a two-sample MR study using GWAS summary statistics data of the UK Biobank. We applied genetically predicted serum albumin as a primary exposure measure and serum total protein as a secondary exposure measure. The outcome measure was the Rockwood frailty index (FI) based on 49 deficits from 356,432 individuals (53.3% of them were women, with a mean ± SD age of 56.7 ± 8.0 y. The association between serum protein measures and FI was mainly analyzed by use of the inverse variance weighted method.
resultsA genetically predicted serum albumin concentration was not statistically significantly associated with FI in the full sample. However, in women, we observed a preventive association between genetically predicted serum albumin and FI (β = -0.172 per g/L; 95% CI: -0.336, -0.007; P = 0.041). In the full sample, genetically predicted serum total protein was inversely associated with FI (β: -0.153 per g/L; 95% CI: -0.251, -0.056; P = 0.002). In both women and men, higher serum total protein was significantly inversely associated with FI; regression coefficients were -0.148 per g/L (95% CI: -0.287, -0.009; P = 0.037) for women, -0.154 per g/L (95% CI: -0.290, -0.018; P = 0.027) for men.
conclusionsThe present MR study implies that better protein nutritional status modestly contributes to reducing the risk of frailty.
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