Evidence map›Paper›PMID 34601554›Full record

ArticleBioinformatics (Oxford, England)2021

RCytoGPS: an R package for reading and visualizing cytogenetics data.

Zachary B Abrams, Dwayne G Tally, Lynne V Abruzzo, Kevin R Coombes

Abstract read
In one paragraph

Article in Bioinformatics (Oxford, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Zachary B AbramsDepartment of Biostatistics, Institute for Informatics, Washington University in St. Louis, St. Louis, MO 63108, USA.ORCID 0000-0001-5219-9996
Dwayne G TallyDepartment of Biology, Indiana State University, Terre Haute, IN 47809, USA.
Lynne V AbruzzoDepartment of Pathology, Wexner Medical Center, The Ohio State University, Columbus, OH 43210, USA.
Kevin R CoombesDepartment of Biomedical Informatics, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0002-7630-2123

Funding

The OSU Clinical and Translational Research Informatics Training Program (CTRIP)T15LM011270 · NLM · OHIO STATE UNIVERSITY · PI COOMBES, KEVIN ROBERT, JANIES, DANIEL A. · 2012 to 2016
$2.2M
BD4ISU: Big Data for Indiana State UniversityR25MD011712 · NIMHD · INDIANA STATE UNIVERSITY · PI BROCK, GUY, COOMBES, KEVIN ROBERT · 2017 to 2020
$1.2M
Secondary Use of Karyotype Data to Predict Outcomes in CLLR03CA235101 · NCI · OHIO STATE UNIVERSITY · PI COOMBES, KEVIN ROBERT · 2019 to 2020
$156k
NCI NIH HHS R03 CA235101NIMHD NIH HHS R25 MD011712NLM NIH HHS T15 LM011270
6 · The paper itself

Abstract

summaryCytogenetics data, or karyotypes, are among the most common clinically used forms of genetic data. Karyotypes are stored as standardized text strings using the International System for Human Cytogenomic Nomenclature (ISCN). Historically, these data have not been used in large-scale computational analyses due to limitations in the ISCN text format and structure. Recently developed computational tools such as CytoGPS have enabled large-scale computational analyses of karyotypes. To further enable such analyses, we have now developed RCytoGPS, an R package that takes JSON files generated from CytoGPS.org and converts them into objects in R. This conversion facilitates the analysis and visualizations of karyotype data. In effect this tool streamlines the process of performing large-scale karyotype analyses, thus advancing the field of computational cytogenetic pathology. AVAILABILITY AND IMPLEMENTATION: Freely available at https://CRAN.R-project.org/package=RCytoGPS. The code for the underlying CytoGPS software can be found at https://github.com/i2-wustl/CytoGPS.

Indexed as

ReadingSoftwareHumansKaryotypeKaryotyping

Identifiers

PMID34601554
PMCPMC10262354

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.