Evidence map›Paper›PMID 34601446›Full record

ArticleDiagnostic microbiology and infectious disease2021

Rapidly fatal infection with Bacillus cereus/thuringiensis: genome assembly of the responsible pathogen and consideration of possibly contributing toxins.

Monica Butcher, Daniela Puiu, Mark Romagnoli, Karen C Carroll, Steven L Salzberg, David W Nauen

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Diagnostic microbiology and infectious disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Pathogenesis of human-derivedFrontiers in cellular and infection microbiology · 2026
    Article
  2. Genomic epidemiology of aMicrobial genomics · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Identification of aHeliyon · 2023
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Monica ButcherDepartment of Pathology and Center for Computational Biology, Johns Hopkins University, Baltimore, MD, USA.
Daniela PuiuDepartment of Pathology and Center for Computational Biology, Johns Hopkins University, Baltimore, MD, USA.
Mark RomagnoliDepartment of Pathology and Center for Computational Biology, Johns Hopkins University, Baltimore, MD, USA.
Karen C CarrollDepartment of Pathology and Center for Computational Biology, Johns Hopkins University, Baltimore, MD, USA.
Steven L SalzbergDepartment of Pathology and Center for Computational Biology, Johns Hopkins University, Baltimore, MD, USA.
David W NauenDepartment of Pathology and Center for Computational Biology, Johns Hopkins University, Baltimore, MD, USA. Electronic address: dwnauen@jhmi.edu.
Johns Hopkins University · US

Funding

Computational Methods for Microbial and Microbiome Sequence AnalysisR35GM130151 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Steven L. Salzberg · 2019 to 2026
$2.9M
Bioinformatics Software for Analyzing Microbial GenomesR01GM083873 · NIGMS · UNIV OF MARYLAND, COLLEGE PARK · PI SALZBERG, STEVEN L. · 2008 to 2017
$2.1M
NIGMS NIH HHS R01 GM083873NIGMS NIH HHS R35 GM130151
6 · The paper itself

Abstract

Bloodstream infection with Bacillus cereus/thuringiensis can be life threatening, particularly in patients who are severely immunocompromised. In this report we describe a case that progressed from asymptomatic to fatal over approximately 5 hours despite extensive resuscitation efforts. We identify the pathogen and assemble its genome, in which we find genes for toxins that may have contributed to the precipitous demise. In the context of this and other cases we discuss the possible indication for rapid appropriate antibiotic administration and potentially antitoxin treatment or toxin removal in fulminant illness in immunocompromised patients.

Indexed as

Bacillus cereusBacillus thuringiensisBacterial ToxinsChild, PreschoolFatal OutcomeFemaleGenome, BacterialGram-Positive Bacterial InfectionsHumansImmunocompromised HostSepsisBacterial ToxinsBacillus cereus/thuringiensishematologic malignancyimmunocompromiseinduction chemotherapysepsis

Identifiers

PMID34601446
PMCPMC9716716
OpenAlexW3200604708

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.