Evidence map›Paper›PMID 34601343›Full record

ArticlePsychoneuroendocrinology2021

Evidence that perinatal ovarian hormones promote women's sexual attraction to men.

Talia N Shirazi, Heather Self, Khytam Dawood, Lisa L M Welling, Rodrigo Cárdenas, Kevin A Rosenfield, J Michael Bailey, Ravikumar Balasubramanian, Angela Delaney, S Marc Breedlove and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychoneuroendocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Talia N ShiraziDepartment of Anthropology, Pennsylvania State University, Carpenter Building, University Park, PA 16802, USA.
Heather SelfDepartment of Anthropology, Pennsylvania State University, Carpenter Building, University Park, PA 16802, USA.
Khytam DawoodDepartment of Psychology, Pennsylvania State University, Moore Building, University Park, PA 16802, USA.
Lisa L M WellingDepartment of Psychology, Oakland University, 212 Pryale Hall, Rochester, MI 48309, USA.
Rodrigo CárdenasDepartment of Psychology, Pennsylvania State University, Moore Building, University Park, PA 16802, USA.
Kevin A RosenfieldDepartment of Anthropology, Pennsylvania State University, Carpenter Building, University Park, PA 16802, USA.
J Michael BaileyDepartment of Psychology, Northwestern University, Swift Hall 303B, Evanston, IL 60208, USA.
Ravikumar BalasubramanianReproductive Endocrine Unit, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA.
Angela DelaneyReproductive Physiology and Pathophysiology Group, National Institutes of Health, 10 Center Drive, Bethesda, MD 20814, USA.
S Marc BreedloveNeuroscience Program and Department of Psychology, Michigan State University, 240 Giltner Hall, East Lansing, MI 48824, USA.
David A PutsDepartment of Anthropology, Pennsylvania State University, Carpenter Building, University Park, PA 16802, USA. Electronic address: dap27@psu.edu.
Pennsylvania State University · USMassachusetts General Hospital · USMichigan State University · USNational Institutes of Health · USNorthwestern University · USOakland University · US

Funding

The Massachusetts General Hospital Harvard Center for Reproductive MedicineP50HD104224 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI SEMINARA, STEPHANIE BETH · 2021 to 2025
$7.8M
Integrative Approaches to Decipher Genetic Determinants of Disease Penetrance in Prokineticin 2 Pathway Related Human Reproductive DisordersR01HD096324 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI BALASUBRAMANIAN, RAVIKUMAR · 2018 to 2022
$1.7M
Integrative Neurobiology of Social ProcessesT32MH070343 · NIMH · MICHIGAN STATE UNIVERSITY · PI BREEDLOVE, S MARC · 2004 to 2013
$1.1M
NICHD NIH HHS P50 HD104224NICHD NIH HHS R01 HD096324NIMH NIH HHS L40 MH078646NIMH NIH HHS T32 MH070343
6 · The paper itself

Abstract

Ovarian estrogens may influence the development of the human brain and behavior, but there are few opportunities to test this possibility. Isolated GnRH deficiency (IGD) is a rare endocrine disorder that could provide evidence for the role of estrogens in organizing sexually differentiated phenotypes: Unlike typical development, development in individuals with IGD is characterized by low or absent gonadal hormone production after the first trimester of gestation. Because external genitalia develop in the first trimester, external appearance is nevertheless concordant with gonadal sex in people with IGD. We therefore investigated the effects of gonadal hormones on sexual orientation by comparing participants with IGD (n = 97) to controls (n = 1670). Women with IGD reported lower male-attraction compared with typically developing women. In contrast, no consistent sexuality differences between IGD and typically developing men were evident. Ovarian hormones after the first trimester appear to influence female-typical dimensions of sexual orientation.

Indexed as

AndrophiliaGynephiliaIsolated GnRH deficiencySex hormonesSexual orientation

Identifiers

PMID34601343
PMCPMC8957625
OpenAlexW3202841999

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.