Evidence map›Paper›PMID 34600565›Full record

ArticleVeterinary research2021

LsrR, the effector of AI-2 quorum sensing, is vital for the H

Hui Wang, Fei Shang, Jiawei Shen, Jingyi Xu, Xiaolin Chen, Jingtian Ni, Lumin Yu, Ting Xue

Open access · goldAbstract read
In one paragraph

Article in Veterinary research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 28 citations in OpenAlex.

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  12. Involvement ofInternational journal of molecular sciences · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Hui Wang *School of Life Sciences, Anhui Agricultural University, Hefei, 230036, Anhui, China.
Fei Shang *School of Life Sciences, Anhui Agricultural University, Hefei, 230036, Anhui, China.
Jiawei ShenSchool of Life Sciences, Anhui Agricultural University, Hefei, 230036, Anhui, China.
Jingyi XuSchool of Life Sciences, Anhui Agricultural University, Hefei, 230036, Anhui, China.
Xiaolin ChenSchool of Life Sciences, Anhui Agricultural University, Hefei, 230036, Anhui, China.
Jingtian NiSchool of Life Sciences, Anhui Agricultural University, Hefei, 230036, Anhui, China.
Lumin YuSchool of Life Sciences, Anhui Agricultural University, Hefei, 230036, Anhui, China. yulumin@lyu.edu.cn.
Ting XueSchool of Life Sciences, Anhui Agricultural University, Hefei, 230036, Anhui, China. xuet@ahau.edu.cn.ORCID http://orcid.org/0000-0002-5644-6613
Anhui Agricultural University · CN

Funding

National Natural Science Foundation of China 31672571
6 · The paper itself

Abstract

Mammary pathogenic Escherichia coli (MPEC) is an important causative agent of mastitis in dairy cows that results in reduced milk quality and production, and is responsible for severe economic losses in the dairy industry worldwide. Oxidative stress, as an imbalance between reactive oxygen species (ROS) and antioxidants, is a stress factor that is common in most bacterial habitats. The presence of ROS can damage cellular sites, including iron-sulfur clusters, cysteine and methionine protein residues, and DNA, and may cause bacterial cell death. Previous studies have reported that Autoinducer 2 (AI-2) can regulate E. coli antibiotic resistance and pathogenicity by mediating the intracellular receptor protein LsrR. This study explored the regulatory mechanism of LsrR on the H

Indexed as

Quorum SensingAnimalsBase SequenceBreast DiseasesCattleCattle DiseasesDNA, BacterialEscherichia coli ProteinsFemaleHomoserineHydrogen PeroxideLactonesMammary Glands, AnimalRepressor ProteinsSequence AlignmentStress, PhysiologicalDNA, BacterialEscherichia coli ProteinsHomoserineHydrogen PeroxideLactonesLsrR protein, E coliN-octanoylhomoserine lactoneRepressor ProteinsAI-2 quorum sensingcow mastitisH2O2LsrRmammary pathogenic Escherichia coli

Identifiers

PMID34600565
PMCPMC8487509
OpenAlexW3202491280

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.