ArticleBMC pediatrics2021
Hypovitaminosis D and risk factors in pediatric epilepsy children.
Article in BMC pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 21 citations in OpenAlex.
- Vitamin D status of pediatric epilepsy patients and evaluation of affecting factors.Italian journal of pediatrics · 2025Article
- Pediatric Headache Patients Are at High Risk of Vitamin D Insufficiency.Journal of child neurology · 2025Article
- Effect of Anti-Seizure Medication Monotherapy on Vitamin D Levels in Indian Children: A Longitudinal Cohort Study.Journal of epilepsy research · 2024Article
- Vitamin D Relieves Epilepsy Symptoms and Neuroinflammation in Juvenile Mice by Activating the mTOR Signaling Pathway via RAF1: Insights from Network Pharmacology and Molecular Docking Studies.Neurochemical research · 2024Article
- Impact of Vitamin D and IL-1β on Quality of Life in Pediatric Drug-Resistant Epilepsy.Journal of multidisciplinary healthcare · 2024Article
- Comparison of 25-hydroxy vitamin D serum levels among children with epilepsy in therapy with single versus multiple antiseizure medications.Epilepsy & behavior reports · 2023Article
- Updates on Sturge-Weber Syndrome.Stroke · 2022Review
- Impact of seborrheic dermatitis on osteoporosis risk: A population-based cohort study.The Journal of dermatology · 2022Article
- Prevalence and Related Risk Factors of Vitamin D Deficiency in Saudi Children with Epilepsy.Children (Basel, Switzerland) · 2022Article
- Association between serum vitamin D status and the anti-seizure treatment in Chinese children with epilepsy.Frontiers in nutrition · 2022Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnti-seizure medication (ASM) treatment is one of the significant risk factors associated with abnormal vitamin D status in epilepsy patients. Multiple studies have shown that adult epilepsy patients can exhibit vitamin D deficiency. However, there are few reports investigating pediatric epilepsy patients. In this study, we aimed to identify risk factors related to hypovitaminosis D in pediatric epilepsy patients in Thailand.
methodsA cross-sectional retrospective cohort study was conducted in 138 pediatric epilepsy patients who received anticonvulsants from April 2018 to January 2019. Demographic data, seizure types, puberty status, physical activity, duration, and types of anti-seizure medications were analyzed. Patients with abnormal liver function, abnormal renal function, and who received vitamin D supplements or ketogenic diet containing vitamin D were excluded. Levels of serum vitamin D (25(OH)D) were measured.
resultsAll 138 subjects were enrolled, the age ranged from 1.04 - 19.96 years; (mean = 9.65 ± 5.09), the mean serum 25(OH) D level was 26.56 ± 9.67 ng/ml. The prevalence of vitamin D deficiency was 23.2% and insufficiency was 47.8% respectively. Two risk factors-puberty status (OR 5.43, 95% CI 1.879-15.67) and non-enzyme-inhibiting ASMs therapy (OR 3.58, 95% CI 1.117-11.46)-were significantly associated with hypovitaminosis D, as shown by multivariate analyses.
conclusionsOur study reports the high prevalence of hypovitaminosis D in pediatric epilepsy patients in Thailand despite being located in the tropical zone. These findings can guide clinicians to measure vitamin D status in pediatric epilepsy patients particularly when they reach puberty and/or are using non-enzyme-inhibiting ASMs therapy. Early detection of vitamin D status and prompt vitamin D supplementation can prevent fractures and osteoporosis later in life.
trial registrationTCTR20210215005 ( http://www.clinicaltrials.in.th/ ).
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