Evidence map›Paper›PMID 34600509›Full record

ArticleBMC complementary medicine and therapies2021

Neuroprotective potentials of selected natural edible oils using enzyme inhibitory, kinetic and simulation approaches.

Mater H Mahnashi, Bandar A Alyami, Yahya S Alqahtani, Ali O Alqarni, Muhammad Saeed Jan, Muhammad Ayaz, Farhat Ullah, Muhammad Shahid, Umer Rashid, Abdul Sadiq

Open access · goldAbstract readComparative Study
In one paragraph

Article in BMC complementary medicine and therapies, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Mater H MahnashiDepartment of Pharmaceutical Chemistry, College of Pharmacy, Najran University, Najran, Saudi Arabia.
Bandar A AlyamiDepartment of Pharmaceutical Chemistry, College of Pharmacy, Najran University, Najran, Saudi Arabia.
Yahya S AlqahtaniDepartment of Pharmaceutical Chemistry, College of Pharmacy, Najran University, Najran, Saudi Arabia.
Ali O AlqarniDepartment of Pharmaceutical Chemistry, College of Pharmacy, Najran University, Najran, Saudi Arabia.
Muhammad Saeed JanDepartment of Pharmacy, University of Swabi, Swabi, KP, Pakistan.
Muhammad AyazDepartment of Pharmacy, Faculty of Biological Sciences, University of Malakand, Chakdara, KP, 18000 Dir (L), Pakistan.
Farhat UllahDepartment of Pharmacy, Faculty of Biological Sciences, University of Malakand, Chakdara, KP, 18000 Dir (L), Pakistan.
Muhammad ShahidDepartment of Pharmacy, Sarhad University of Science and Information Technology, Peshawar, Khyber Pakhtunkhwa, 25000, Pakistan.
Umer RashidDepartment of Chemistry, COMSATS University Islamabad, Abbottabad Campus, Abbottabad, 22060, Pakistan.
Abdul SadiqDepartment of Pharmacy, Faculty of Biological Sciences, University of Malakand, Chakdara, KP, 18000 Dir (L), Pakistan. sadiquom@yahoo.com.
Najran University · SAUniversity of Malakand · PKCOMSATS University Islamabad · PKSarhad University of Science and Information Technology · PKUniversity of Swabi · PK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEdible oils have proven health benefits in the prevention and treatment of various disorders since the establishment of human era. This study was aimed to appraise neuropharmacological studies on the commonly used edible oils including Cinnamomum verum (CV), Zingiber officinale (ZO) and Cuminum cyminum (CC).

methodsThe oils were analyzed via GC-MS for identifications of bioactive compounds. Anti-radicals capacity of the oils were evaluated via 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radicals scavenging assays. The samples were also tested against two important acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) which are among the important drug targets in Alzheimer's disease. Lineweaver-Burk plots were constructed for enzyme inhibition studies which correspond to velocity of enzymes (V

results(Gas chromatography-mass spectrometry GC-MS) analysis revealed the presence of thirty-four compounds in Cinnamon oil (Cv.Eo), fourteen in ginger oil (Zo.Eo) and fifty-six in cumin oil (Cc.Eo). In the antioxidant assays, Cv.Eo, Zo.Eo and Cc.Eo exhibited IC

Indexed as

Cinnamomum zeylanicumCuminumZingiber officinaleAntioxidantsEnzyme InhibitorsGas Chromatography-Mass SpectrometryHumansMolecular Docking SimulationNeuroprotective AgentsPharmacokineticsPlant OilsAntioxidantsEnzyme InhibitorsNeuroprotective AgentsPlant OilsAlzheimer’s diseaseCholinesterase’sCinnamon and GC-MSCuminFree radicalsFunctional foodsGinger

Identifiers

PMID34600509
PMCPMC8487577
OpenAlexW3202663553

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.