Evidence map›Paper›PMID 34600477›Full record

ArticleBMC infectious diseases2021

Viral suppression among HIV-positive patients on antiretroviral therapy in northwestern Nigeria: an eleven-year review of tertiary care centre records, January 2009-December 2019.

Suleiman Bello Abdullahi, Olayinka Rasheed Ibrahim, Abdulkadir Baba Okeji, Rabilu Iliyasu Yandoma, Ibrahim Bashir, Suleiman Haladu, Suleiman Ahmad Idris, T I A Oseni, Bello Muhammad Suleiman, Mohammed Yahaya and 2 more

Abstract read
In one paragraph

Article in BMC infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Suleiman Bello AbdullahiDepartment of Family Medicine, Federal Medical Centre, Murtala Mohammed Way (Jibia Bypass), P. M. B: 2121, Katsina, Nigeria. bellonsaleehawa@gmail.com.
Olayinka Rasheed IbrahimDepartment of Paediatrics, Federal Medical Centre, Katsina, Nigeria.
Abdulkadir Baba OkejiDepartment of Family Medicine, Federal Medical Centre, Lokoja, Nigeria.
Rabilu Iliyasu YandomaDepartment of Family Medicine, Federal Medical Centre, Murtala Mohammed Way (Jibia Bypass), P. M. B: 2121, Katsina, Nigeria.
Ibrahim BashirDepartment of Haematology and Blood Transfusion, Federal Medical Centre, Katsina, Nigeria.
Suleiman HaladuNigeria Field Epidemiology and Laboratory Training Programme, Abuja, Nigeria.
Suleiman Ahmad IdrisNigeria Field Epidemiology and Laboratory Training Programme, Abuja, Nigeria.
T I A OseniDepartment of Family Medicine, Ambrose Alli University, Ekpoma, Nigeria.
Bello Muhammad SuleimanDepartment of Paediatrics, Federal Medical Centre, Katsina, Nigeria.
Mohammed YahayaDepartment of Medical Microbiology and Parasitology, Usmanu Danfodiyo University, Sokoto, Nigeria.
Mabel Kamweli AworhNigeria Field Epidemiology and Laboratory Training Programme, Abuja, Nigeria.
Mu'awiyyah Babale SufiyanDepartment of Community Medicine, Ahmadu Bello University Zaria, Kaduna, Nigeria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHuman Immuno-Deficiency Virus (HIV) remains one of the world's significant public health challenges. Viral suppression is the key indicator for treatment success in People living with HIV (PLHIV). We determined the level of viral suppression, and its associated factors among PLHIV attending Federal Medical Centre Katsina (FMC Katsina), Nigeria.

methodsThis retrospective descriptive cross-sectional study was conducted on 913 HIV positive adults enrolled in care between January 2009 and December 2019. Information on socio-demographics, clinical, immunological, Viral load (VL), and other relevant parameters were extracted from the patients' care records. The primary outcome was the proportion of patients that achieved viral suppression. We also analyzed variables that were associated with VL suppression.

resultsOf 913, records of 831 (91.0%) registered patients were analyzed. During the period, 751 (90.4%) achieved viral suppression, 427 (51.4%) had CD4 counts  ≥ 500 and 477 (57.4%) were on HAART for ≥ 5 years. Majority, 793 (95.4%) were on first-line HAART regimen (Tenofovir-Lamivudine-Dolutegravir or Abacavir-Lamivudine-Dolutegravir), and 809 (97.4%) in the non-advanced stage (WHO stages 1 and 2). The median (interquartile range) of viral load was 20 (20-40) vs 19,989 (3311-110,340) cp/ml in virally suppressed, and unsuppressed  respectively. Factors associated with viral suppression included being unemployed (Adjusted OR [AOR] 4.9, 95% CI 2.771, 8.539), educated (AOR 4.2, 95% CI 1.098, 16.223), having a baseline CD4 count ≥ 500 cells/µl (AOR 2.7, 95% CI 1.588, 4.625), and being on first line HAART regimen [AOR 7.0, 95% CI 3.220, 15.648].

conclusionsOur study demonstrated a good viral suppression among PLHIV on HAART. Variables associated with viral suppression included unemployment, formal education, high baseline CD4 count, and first line HAART regimen.

Indexed as

Anti-HIV AgentsHIV InfectionsAntiretroviral Therapy, Highly ActiveCD4 Lymphocyte CountCross-Sectional StudiesHumansNigeriaRetrospective StudiesTertiary Care CentersViral LoadAnti-HIV AgentsAntiretroviral TherapyHIV-PositivesNigeriaViral suppression

Identifiers

PMID34600477
PMCPMC8487150

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.