Evidence map›Paper›PMID 34600248›Full record

ArticleDrug and alcohol dependence2021

Non-fatal stimulant overdose among homeless and unstably housed women in San Francisco, California.

Thibaut Davy-Mendez, Eric Vittinghoff, Samantha E Dilworth, Leslie W Suen, Carl Braun, Phillip O Coffin, Derek D Satre, Elise D Riley

Open access · greenAbstract read
In one paragraph

Article in Drug and alcohol dependence, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Housing Instability Associated with Return to Stimulant Use among Previously Abstaining Women.International journal of environmental research and public health · 2023
    Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Thibaut Davy-MendezDepartment of Psychiatry and Behavioral Sciences, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA; Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
Eric VittinghoffDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.
Samantha E DilworthDepartment of Medicine, University of California, San Francisco, CA, USA.
Leslie W SuenDepartment of Medicine, University of California, San Francisco, CA, USA.
Carl BraunDepartment of Medicine, University of California, San Francisco, CA, USA.
Phillip O CoffinDepartment of Medicine, University of California, San Francisco, CA, USA; San Francisco Department of Public Health, San Francisco, CA, USA.
Derek D SatreDepartment of Psychiatry and Behavioral Sciences, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA; Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
Elise D RileyDepartment of Medicine, University of California, San Francisco, CA, USA.
University of California, San Francisco · USKaiser Permanente · US

Funding

Clinical and Translational Science InstituteUL1TR001872 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI COLLARD, HAROLD R, JACOBY, VANESSA · 2016 to 2025
$112.1M
Substance Use Disorders Treatment/Services Research Training ProgramT32DA007250 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Derek D Satre, Janice Y Tsoh · 1991 to 2026
$7.4M
Impact of Cocaine and Polydrug Use on Cranial Small Vessel DiseaseR01DA037012 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RILEY, ELISE D. · 2014 to 2018
$4.1M
Cocaine use, viral suppression and precursors of stroke in HIV infectionR01DA049648 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RILEY, ELISE D. · 2020 to 2024
$4.0M
Mentoring patient-oriented research on the health consequences of polydrug useK24DA039780 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RILEY, ELISE D. · 2015 to 2025
$1.9M
Midcareer K24 Award for Mentoring and Patient-Oriented ResearchK24DA042720 · NIDA · SAN FRANCISCO DEPARTMENT OF PUBLIC HEALTH · PI PHILLIP O COFFIN · 2016 to 2026
$1.6M
Enhancing Resident Investigation and Career Advancement in Cardiovascular and Pulmonary ScienceR38HL143581 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BIBBINS-DOMINGO, KIRSTEN, HUANG, ALISON · 2018 to 2021
$1.4M
NCATS NIH HHS UL1 TR001872NHLBI NIH HHS R38 HL143581NIDA NIH HHS K24 DA039780NIDA NIH HHS K24 DA042720NIDA NIH HHS R01 DA037012NIDA NIH HHS R01 DA049648NIDA NIH HHS T32 DA007250
6 · The paper itself

Abstract

backgroundUS rates of overdose deaths involving stimulants (e.g., cocaine or methamphetamine) have increased, but little is known about non-fatal stimulant overdoses, particularly among vulnerable populations. We characterized rates of non-fatal stimulant overdose identified outside of health care settings among women at high risk.

methodsHomeless and unstably housed women in San Francisco, California using stimulants were administered questionnaires on drug use and outcomes (stimulant overdose, health care utilization) monthly for six months. Based on pilot interviews, stimulant overdose during follow-up was defined as acute toxicity from stimulant use ("over-amping") resulting in "feeling sick, really scared, or like one's life may be in danger". Poisson regression estimated unadjusted incidence rate ratio (IRR) comparing participant characteristics.

resultsWe included 160 women (41% Black, 26% White, 15% Latina, median age 54 years) using crack cocaine (81%), methamphetamine (48%), and powdered cocaine (36%). Participants reported 67 non-fatal stimulant overdoses over 685 person-months of observation, a rate of 117.4 per 100 person-years (95% CI 85.8-160.5). Rates were higher among participants who were Latina vs. White (IRR 4.18 [1.60-10.94]), used methamphetamine (IRR 1.80 [0.96-3.38]), or used any stimulant daily/almost daily (IRR 2.63 [1.41-4.91]). Among women reporting stimulant overdose, 4% received emergency and 3% inpatient care for overdose of any drug.

conclusionsWomen in this setting, particularly those who used stimulants frequently or used methamphetamine, experienced high non-fatal stimulant overdose and rarely received health care for these events. Efforts should be made to increase awareness and reduce harms of stimulant toxicity in vulnerable populations.

Indexed as

Central Nervous System StimulantsDrug OverdoseIll-Housed PersonsMethamphetamineFemaleHumansMiddle AgedSan FranciscoCentral Nervous System StimulantsMethamphetamineCocaineHIVHomelessMethamphetamineOverdoseStimulantUnshelteredWomen

Identifiers

PMID34600248
PMCPMC8595709
OpenAlexW3201420777

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.