ArticleResuscitation2021
Deviations from NIRS-derived optimal blood pressure are associated with worse outcomes after pediatric cardiac arrest.
Article in Resuscitation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Relationship Between Cerebral Oximetry and Outcomes in Post-Cardiac Arrest Patients: A Systematic Review and Meta-Analysis.Critical care explorations · 2026Pooled it
- Monitoring of Cerebral Blood Flow Autoregulation after Cardiac Arrest.Medicina (Kaunas, Lithuania) · 2024Pooled it
- Non-invasive cerebral oxygenation and blood pressure neuromonitoring characterizes dynamic cerebrovascular autoregulation following cardiac arrest.Resuscitation plus · 2026Article
- Cerebral Autoregulation and Optimal Blood Pressure from Birth to Surgery in Neonates with Critical Congenital Heart Disease.Pediatric cardiology · 2026Observational
- Autonomic Function and Cerebral Autoregulation in Children Receiving Extracorporeal Life Support.Children (Basel, Switzerland) · 2026Article
- Wolf Creek XVIII Part 8: Wolf Creek Innovator in Cardiac Arrest and Resuscitation Science Award.Resuscitation plus · 2026Article
- Data pipeline quality: development and validation of a quality assessment tool for data-driven algorithms and artificial intelligence in healthcare.BMJ health & care informatics · 2026Article
- The Relationship Between Pressure Reactivity and Cerebral Oximetry Indexes in Patients with Aneurysmal Subarachnoid Hemorrhage: A Single-Center Pilot Study.Neurocritical care · 2025Article
- Cerebral oxygen monitoring during out-of-hospital cardiac arrest: A scoping review.Resuscitation plus · 2025Review
- Association Between Deviations From Cerebral Autoregulation-Derived Optimal Blood Pressure and Outcome After Pediatric Cardiac Arrest.Neurology · 2025Article
- Optimal mean arterial pressure and its objective statistical associations with clinical outcomes and multimodal monitoring cerebral physiology: A systematic scoping review.Physiological reports · 2025Article
- Impaired Cerebral Autoregulation in Children.Pediatric neurology · 2025Review
- Comprehensive pre- and in-hospital near-infrared-spectroscopy (NIRS) monitoring after return of spontaneous circulation predicts neurological outcome following out-of-hospital cardiac arrest: a prospective observational study and literature review.Frontiers in medicine · 2025Article
- Plasma brain-related biomarkers and potential therapeutic targets in pediatric ECMO.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Review
- Cerebral autoregulation in pediatric and neonatal intensive care: A scoping review.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Cerebral autoregulation, spreading depolarization, and implications for targeted therapy in brain injury and ischemia.Reviews in the neurosciences · 2024Review
- Neuromonitoring in Pediatric Neurocritical Care: An Introduction.Neurocritical care · 2024Article
- Effect of dimethyl fumarate on mitochondrial metabolism in a pediatric porcine model of asphyxia-induced in-hospital cardiac arrest.Scientific reports · 2024Article
- The State of the Field of Pediatric Multimodality Neuromonitoring.Neurocritical care · 2024Review
- Neurophysiologic Features Reflecting Brain Injury During Pediatric ECMO Support.Neurocritical care · 2024Observational
Corrections and comments
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Authors and funding
16 authors at 3 institutions in 1 country.
Funding
Abstract
aimEvaluate cerebrovascular autoregulation (CAR) using near-infrared spectroscopy (NIRS) after pediatric cardiac arrest and determine if deviations from CAR-derived optimal mean arterial pressure (MAP
methodsCAR was quantified by a moving, linear correlation between time-synchronized mean arterial pressure (MAP) and regional cerebral oxygenation, called cerebral oximetry index (COx). MAP
resultsThirty-four children (median age 2.9 [IQR 1.5,13.4] years) were evaluated. Median COx in the first 24 h post-cardiac arrest was 0.06 [0,0.20]; patients spent 27% [19,43] of monitored time with COx ≥ 0.3. Patients with an unfavorable outcome (n = 24) had a greater difference between MAP and MAPopt - 5 (13 [11,19] vs. 9 [8,10] mmHg, p = 0.01) and spent more time with MAP below MAPopt - 5 (38% [26,61] vs. 24% [14,28], p = 0.03). Patients with unfavorable outcome had a higher burden of MAP less than MAPopt - 5 than patients with favorable outcome in the first 24 h post-arrest (187 [107,316] vs. 62 [43,102] mmHg × Min/Hr; OR 4.93 [95% CI 1.16-51.78]).
conclusionsGreater burden of MAP below NIRS-derived MAPopt - 5 during the first 24 h after cardiac arrest was associated with unfavorable outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.