ArticleThe American journal of pathology2022
METTL3 Regulates Liver Homeostasis, Hepatocyte Ploidy, and Circadian Rhythm-Controlled Gene Expression in Mice.
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Article in The American journal of pathology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
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Who cites it
23 citing papers in PubMed, 42 citations in OpenAlex.
- Short-term methionine starvation induces de novo diurnal oscillations of hepatic m6A RNA methylation.bioRxiv : the preprint server for biology · 2026Article
- FTO-mediated NR1D1 mScientific reports · 2026Article
- Hepatocyte Mettl3 Deficiency Drives Primary Sclerosing Cholangitis and Liver Fibrosis via Cholangiocyte-Macrophage Crosstalk.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- NBiomolecules · 2026Review
- METTL3: a multifunctional regulator in diseases.Molecular and cellular biochemistry · 2025Review
- METTL14-Induced MAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Liver-specific Mettl14 deletion induces nuclear heterotypia and dysregulates RNA export machinery.bioRxiv : the preprint server for biology · 2024Article
- Article
- Polyploidy Promotes Hypertranscription, Apoptosis Resistance, and Ciliogenesis in Cancer Cells and Mesenchymal Stem Cells of Various Origins: Comparative Transcriptome In Silico Study.International journal of molecular sciences · 2024Article
- Hepatocyte-specific Wtap deficiency promotes hepatocellular carcinoma by activating GRB2-ERK depending on downregulation of proteasome-related genes.The Journal of biological chemistry · 2023Article
- Altered splicing factor and alternative splicing events in a mouse model of diet- and polychlorinated biphenyl-induced liver disease.Environmental toxicology and pharmacology · 2023Article
- METTL3 drives NAFLD-related hepatocellular carcinoma and is a therapeutic target for boosting immunotherapy.Cell reports. Medicine · 2023Article
- Mettl3-mediated mAging · 2023Article
- Disruption of the mouse liver epitranscriptome by long-term aroclor 1260 exposure.Environmental toxicology and pharmacology · 2023Article
- mNature metabolism · 2023Article
- Article
- Photoperiod alters testicular methyltransferase complex mRNA expression in Siberian hamsters.General and comparative endocrinology · 2023Article
- Critical roles of mFrontiers in cardiovascular medicine · 2023Review
- Emerging role of METTL3 in inflammatory diseases: mechanisms and therapeutic applications.Frontiers in immunology · 2023Review
- RNA m6A modification in liver biology and its implication in hepatic diseases and carcinogenesis.American journal of physiology. Cell physiology · 2022Review
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 1 country.
Juan M BarajasDepartment of Pathology, The Ohio State University, Columbus, Ohio.
Cho-Hao LinDepartment of Pathology, The Ohio State University, Columbus, Ohio; Comprehensive Cancer Center, College of Medicine, The Ohio State University, Columbus, Ohio.
Hui-Lung SunDepartment of Biochemistry and Molecular Biology and Institute for Biophysical Dynamics, Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois.
Frances AlencastroDepartment of Pathology, Pittsburgh Liver Research Center, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pennsylvania.
Allen C ZhuDepartment of Biochemistry and Molecular Biology and Institute for Biophysical Dynamics, Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois.
Mona AljuhaniDepartment of Pathology, The Ohio State University, Columbus, Ohio.
Ladan NavariComprehensive Cancer Center, College of Medicine, The Ohio State University, Columbus, Ohio.
Selen A YilmazDepartment of Biomedical Informatics, The Ohio State University, Columbus, Ohio.
Lianbo YuDepartment of Biomedical Informatics, The Ohio State University, Columbus, Ohio.
Kara CorpsDepartment of Veterinary Biosciences, The Ohio State University, Columbus, Ohio.
Chuan HeDepartment of Biochemistry and Molecular Biology and Institute for Biophysical Dynamics, Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois.
Andrew W DuncanDepartment of Pathology, Pittsburgh Liver Research Center, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pennsylvania. Electronic address: duncana@pitt.edu.
Kalpana GhoshalDepartment of Pathology, The Ohio State University, Columbus, Ohio; Comprehensive Cancer Center, College of Medicine, The Ohio State University, Columbus, Ohio. Electronic address: ghoshall@gmail.com.
The Ohio State University · USHoward Hughes Medical Institute · USUniversity of Pittsburgh · US
Funding
Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Jennifer A. Woyach · 1985 to 2026
$132.3MTranscriptome-wide base-resolution sequencing of pseudouridine in human normal and AD brain tissues-CEGS Admin supplement 2020-2021RM1HG008935 · NHGRI · UNIVERSITY OF CHICAGO · PI HE, CHUAN · 2016 to 2025
$24.4MPittsburgh Liver Research CenterP30DK120531 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DAVID A GELLER · 2019 to 2026
$10.9MMechanisms of Polyploidy and Aneuploidy in the LiverR01DK103645 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DUNCAN, ANDREW W · 2014 to 2023
$4.1MRole of microR-122 in Hepatocarcinogenesis using Conditional Knockout MiceR01CA193244 · NCI · OHIO STATE UNIVERSITY · PI GHOSHAL, KALPANA · 2015 to 2019
$2.3MThe Effects of ERK2-Induced Phosphorylation of METTL3 on N6-methyladenosine (m6A) mRNA Methylation in MelanomaF30CA247175 · NCI · UNIVERSITY OF CHICAGO · PI ZHU, ALLEN C · 2020 to 2023
$192kFunctional evaluation of clonal hematopoiesis of indeterminate potential (CHIP)F32HL154636 · NHLBI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI BARAJAS, JUAN M. · 2020 to 2021
$130kNCI NIH HHS F30 CA247175NCI NIH HHS P30 CA016058NCI NIH HHS R01 CA193244NHGRI NIH HHS RM1 HG008935NHLBI NIH HHS F32 HL154636NHLBI NIH HHS L40 HL154193NIDDK NIH HHS P30 DK120531NIDDK NIH HHS R01 DK103645
Abstract
N
Indexed as
Gene Expression RegulationHomeostasisPloidiesAnimalsAnimals, NewbornARNTL Transcription FactorsBase SequenceCell Cycle ProteinsCell NucleusCircadian RhythmCLOCK ProteinsDNA MethylationGene DeletionGene Expression ProfilingHepatocytesLiverARNTL Transcription FactorsBmal1 protein, mouseCell Cycle ProteinsCLOCK ProteinsMethyltransferasesMettl3 protein, mouseProtein-Tyrosine KinasesWee1 protein, mouse
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.