Evidence map›Paper›PMID 34599855›Full record

ArticleESC heart failure2021

Impact of weight loss in patients with heart failure with preserved ejection fraction: results from the FLAGSHIP study.

Kenta Kamisaka, Kuniyasu Kamiya, Kotaro Iwatsu, Naoki Iritani, Shota Imoto, Takuji Adachi, Yuki Iida, Sumio Yamada, FLAGSHIP collaborators

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in ESC heart failure, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Emerging Role of Weight-Loss Medications in the Management of Heart Failure: Current Evidence and Future Perspectives.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 1 country.

Kenta KamisakaDepartment of Rehabilitation, Kitano Hospital, Osaka, Japan.
Kuniyasu KamiyaDepartment of Hygiene and Public Health, Osaka Medical and Pharmaceutical University, Takatsuki, Japan.
Kotaro IwatsuDepartment of Rehabilitation, Hirakata Kohsai Hospital, Hirakata, Japan.
Naoki IritaniDepartment of Rehabilitation, Toyohashi Heart Center, Toyohashi, Japan.
Shota ImotoDepartment of Rehabilitation, Kainan Hospital, Yatomi, Japan.
Takuji AdachiDepartment of Integrated Health Sciences, Nagoya University Graduate School of Medicine, 1-1-20, Daiko-minami, Higashi-ku, Nagoya, 4618673, Japan.
Yuki IidaDepartment of Physical Therapy, Toyohashi SOZO University School of Health Sciences, Toyohashi, Japan.
Sumio YamadaDepartment of Integrated Health Sciences, Nagoya University Graduate School of Medicine, 1-1-20, Daiko-minami, Higashi-ku, Nagoya, 4618673, Japan.
FLAGSHIP collaborators
Nagoya University · JPKinan Hospital · JPKitano Hospital · JPMunicipal Hirakata City Hospital · JPOsaka University of Pharmaceutical Sciences · JPToyohashi Heart Center · JPToyohashi Sozo College · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsWeight loss (WL) is a poor prognostic factor for patients with heart failure (HF) with reduced ejection fraction. However, its prognostic impact on patients with HF with preserved ejection fraction (HFpEF) remains unestablished. The evidence regarding the effects of obesity on the prognosis of WL is also unclear. We aimed to identify the risk factors for WL and examine the association between WL and prognosis of HFpEF in obese and non-obese patients. METHODS AND

resultsIn this multicentre cohort study, the data of 573 patients hospitalized with HFpEF [median age: 78 years (interquartile range, 71-84 years); 49.2% female] were identified from hospital databases. WL was defined as ≥5% weight reduction within 6 months after discharge. Obesity was defined according to Japanese criteria as body mass index ≥25 kg/m

conclusionsWeight loss should be considered as an indicator for monitoring worsening of HF condition in non-obese patients with HFpEF. WL was not associated with adverse events in obese patients with HFpEF, possibly due to appropriate fluid management during follow-up.

Indexed as

Heart FailureWeight LossAgedCohort StudiesFemaleHumansMaleNatriuretic Peptide, BrainPrognosisStroke VolumeNatriuretic Peptide, BrainCachexiaCohort studyHeart failure with preserved ejection fractionObesityPrognosisWeight loss

Identifiers

PMID34599855
PMCPMC8712923
OpenAlexW3203343202

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.