Evidence map›Paper›PMID 34599832›Full record

ArticleClinical cardiology2021

The association of interferon-alpha with development of collateral circulation after artery occlusion.

Zhenhua Xing, Xiaopu Wang, Junyu Pei, Zhaowei Zhu, Shi Tai, Xinqun Hu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Zhenhua XingDepartment of Emergency Medicine, The Second Xiangya Hospital, Central South University, Changsha, China.
Xiaopu WangDepartment of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, China.
Junyu PeiDepartment of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, China.
Zhaowei ZhuDepartment of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, China.
Shi TaiDepartment of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, China.
Xinqun HuDepartment of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, China.ORCID https://orcid.org/0000-0003-1430-4833
Central South University · CN

Funding

National Science Foundation of China 82000298Natural Science Foundation of Hunan Province 2021JJ40883
6 · The paper itself

Abstract

backgroundPrevious studies have demonstrated that interferon (IFN) signaling is enhanced in patients with poor collateral circulation (CC). However, the role and mechanisms of IFN-alpha in the development of CC remain unknown.

methodsWe studied the serum levels of IFN-alpha and coronary CC in a case-control study using logistics regression, including 114 coronary chronic total occlusion (CTO) patients with good coronary CC and 94 CTO patients with poor coronary CC. Restricted cubic splines was used to flexibly model the association of the levels of IFN-alpha with the incidence of good CC perfusion restoration after systemic treatment with IFN-alpha was assessed in a mice hind-limb ischemia model.

resultsCompared with the first IFN-alpha tertile, the risk of poor CC was higher in the third IFN-alpha tertile (OR: 4.79, 95% CI: 2.22-10.4, p < .001). A cubic spline-smoothing curve showed that the risk of poor CC increased with increasing levels of serum IFN-alpha. IFN-alpha inhibited the development of CC in a hindlimb ischemia model. Arterioles of CC in the IFN-alpha group were smaller in diameter than in the control group.

conclusionPatients with CTO and with poor CC have higher serum levels of IFN-alpha than CTO patients with good CC. IFN-alpha might impair the development of CC after artery occlusion.

Indexed as

Coronary OcclusionPercutaneous Coronary InterventionAnimalsArteriesCase-Control StudiesChronic DiseaseCollateral CirculationCoronary AngiographyCoronary CirculationHumansInterferon-alphaMiceInterferon-alphacollateral circulationcoronary chronic total occlusionIFN-alpha

Identifiers

PMID34599832
PMCPMC8571556
OpenAlexW3203727531

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.