Evidence map›Paper›PMID 34599710›Full record

ArticleEnvironmental science and pollution research international2022

Chronic exposure to lead acetate promotes changes in the alveolar bone of rats: microstructural and physical-chemical characterization.

Lodinikki Lemoy Davis, Walessa Alana Bragança Aragão, Géssica de Oliveira Lopes, Luciana Guimaraes Eiró, Alexandre Rodrigues Freire, Felippe Bevilacqua Prado, Ana Cláudia Rossi, Allan da Silva Cruz, Kelly das Graças Fernandes Dantas, Alan Rodrigo Leal Albuquerque and 3 more

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Article in Environmental science and pollution research international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lodinikki Lemoy Davis *Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Augusto Corrêa street, N. 1. Campus do Guamá. - CEP, Belém, PA, 66075-110, Brazil.
Walessa Alana Bragança Aragão *Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Augusto Corrêa street, N. 1. Campus do Guamá. - CEP, Belém, PA, 66075-110, Brazil.
Géssica de Oliveira LopesLaboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Augusto Corrêa street, N. 1. Campus do Guamá. - CEP, Belém, PA, 66075-110, Brazil.
Luciana Guimaraes EiróLaboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Augusto Corrêa street, N. 1. Campus do Guamá. - CEP, Belém, PA, 66075-110, Brazil.
Alexandre Rodrigues FreireLaboratory of research in Mechanobiology, Piracicaba Dental School, University of Campinas - UNICAMP, Piracicaba, Brazil.
Felippe Bevilacqua PradoLaboratory of research in Mechanobiology, Piracicaba Dental School, University of Campinas - UNICAMP, Piracicaba, Brazil.
Ana Cláudia RossiLaboratory of research in Mechanobiology, Piracicaba Dental School, University of Campinas - UNICAMP, Piracicaba, Brazil.
Allan da Silva CruzGroup of Applied Analytical Spectrometry, Institute of Natural and Exact Sciences, Federal University of Pará, Belém, PA, Brazil.
Kelly das Graças Fernandes DantasGroup of Applied Analytical Spectrometry, Institute of Natural and Exact Sciences, Federal University of Pará, Belém, PA, Brazil.
Alan Rodrigo Leal AlbuquerqueGroup of Applied Analytical Spectrometry, Institute of Natural and Exact Sciences, Federal University of Pará, Belém, PA, Brazil.
Simone Patricia Aranha PazGroup of Applied Analytical Spectrometry, Institute of Natural and Exact Sciences, Federal University of Pará, Belém, PA, Brazil.
Rômulo Simões AngélicaLaboratory of Mineral Characterization, Institute of Geology and Geochemistry, Federal University of Pará, Belém, PA, Brazil.
Rafael Rodrigues LimaLaboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Augusto Corrêa street, N. 1. Campus do Guamá. - CEP, Belém, PA, 66075-110, Brazil. rafalima@ufpa.br.ORCID http://orcid.org/0000-0003-1486-4013

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There are a few data relating to the effects of lead (Pb) exposure on the alveolar bone, which has very distinct morphophysiological characteristics and is of great importance in the oral cavity. In this context, the aim of this study was to investigate the changes promoted after long-term exposure to Pb in the microstructure of the alveolar bone of rats. Twenty adult Wistar rats were exposed to 50 mg/kg/day of lead acetate for 55 days. These animals were euthanized and had their mandible removed. Each mandible was divided into hemimandibles, and the alveolar bone was used for bone lead quantification, crystallinity analysis, microstructure evaluation by the percentage of bone volume (BV/TV), number of trabeculae (Tb.N), thickness of the trabecular (Tb.Th), and trabecular space (Tb.Sp). Morphometric analysis of the exposed root area was also performed. Long-term exposure to Pb resulted in high levels of Pb in the alveolar bone but showed no changes in the organization of crystallinity. The microstructural analyses showed a reduction of BV/TV, Tb.Th, and Tb.N and increase of Tb.Sp parameters, resulting in an increase in the exposed root area and an alveolar bone loss in height. The findings of this study reveal the ability of Pb to alter the alveolar bone microstructure after long-term exposure to the metal, possibly due to changes in tissue homeostasis, contributing to the reduction of bone quality.

Indexed as

Bone and BonesLeadAcetatesAnimalsRatsRats, WistarX-Ray MicrotomographyAcetatesLeadAlveolar bone lossEnvironmental exposureLeadMicroCTPeriodontiumToxicology

Identifiers

PMID34599710

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.