ArticleIntensive care medicine2021
Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021.
31 registry-linked trialsAbstract read
In one paragraph
Article in Intensive care medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 31 registered trials, which are not on this map. Cited by 2,604 papers, 6 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
2,604citing papers in PubMed, 6 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
ED Tracking Sheet Implementation
Does Targeted Abdominal Perfusion Pressure Reduce Renal Injury and Mortality in Septic Shock Patients? A Prospective Controlled Trial
Timing of Preload Responsiveness in Sepsis and Septic Shock
Platform Adaptive Embedded Trial for Acute Respiratory Distress Syndrome
Clinical Study to Improve the Quality of Care in Critically Ill Patients With Suspected Sepsis Through Early Molecular Diagnosis .
PERi-operative Selective Decontamination of the Digestive Tract to Prevent Severe Infectious Complications After Esophagectomy: a Randomized Multicenter Clinical Trial in Patients with Primary Resectable Esophageal Carcinoma (cT1-4, N0-3, M0)
Effect of Personalized Hemodynamic Management Based on Serum Renin Concentration on Acute Kidney Injury Progression in Patients With Shock: a Randomized Controlled Trial.
Comparison Between HA330 Hemoperfusion Filter Hemodialysis and Conventional High-Flux Filter Hemodialysis in Reducing Inflammatory Mediators in Renal Dysfunction Due to Sepsis
Evaluation of the Relationship of Neutrophil Functions With Sepsis and Septic Shock Using the Leukocyte ImmunoTest™ in Patients With Various Infectious Conditions
Intrarenal Venous Flow Change During Fluid Removal in Critically Ill Patients: A Prospective Exploratory Study
Guideline-recommended Basic Parameter Adherence in Neurocritical Care Patients: German-wide Observational Multicenter Individual Participant Data Meta-analysis
Prospective Multicentre Observational Study of Patients Treated With Vasopressin in Critical Care Units
Director, Head of Anesthesiology and Critical Care, Principal Investigator, Professor
Effects of an Online Escape Room on Enhancing Nurses' Knowledge, Clinical Reasoning, and Self-Efficacy Regarding Early Warning Signs of Sepsis: A Randomized Controlled Trial
Angiotensin II Stress Test. Renin Kinetics During Treatment of Vasoplegic Shock With Angiotensin II in Relation to Hemodynamic Response to Treatment With Angiotensin II.
The Impact of Modified Site for Radial Artery Cannulation on the Stability of Arterial Blood Pressure Monitoring
NCT06650384 phase2 / phase3completednot on this mapstarted 2024, after this paper: background citation
Evaluation of the Efficacy and Safety of N-Acetylcysteine Versus Alpha-Lipoic Acid on the Occurrence and Severity of Colistin-Induced Nephrotoxicity in Critically Ill Patients
Comparison of IL-40 and IL-41 Levels in Patients With Sepsis and Septic Shock to Healthy Individuals
Prognostic Value of Procalcitonin Vs Platelet/Total Leukocytic Count Ratio in 28 Days Outcome in Severe Septic Patients
The Effect of Extracorporeal Sepsis Adsorption Column Use on Plasma Syndecan-1 Level and Mortality in Sepsis Patients
NCT07096310 phase1 / phase2active not recruitingnot on this mapstarted 2024, after this paper: background citation
Comparison Between Carbapenems and Noncarbapenem Broad Spectrum Beta-lactam Antibiotics as Initial Antibiotic Therapy Against Sepsis in Burn Patients: A Prospective Study
Predictive Model for Multidrug Resistance in Patients Admitted to the Emergency Department With Sepsis
Efficacy and Safety of Balanced Gelatin Solution for Fluid Infusion in Sepsis Patients Undergoing Emergency Abdominal Surgery: A Multicenter, Adaptive Designed, Randomized Controlled Trial
Veno-arterial Carbon Dioxide Partial Pressure Difference (CO2gap) for Early Resuscitation of Septic Shock: A Multicenter Prospective Randomized Trial (CARBON)
NCT07240701 phase4not yet recruitingnot on this mapstarted 2025, after this paper: background citation
A Prospective, Single-Center, Randomized Controlled Trial Comparing Normal Saline and Ringer's Lactate for Initial Fluid Resuscitation in Adult Patients With Sepsis in the Emergency Department
PAN-ICIS: Prospective Observational Study Evaluating the Intensive Care Infection Score for Early Detection of Infectious Complications After Pancreatic Resections
Immunomodulatory Effect of Curcumin in Critically Ill Patients With Sepsis at the Antiguo Hospital Civil de Guadalajara "Fray Antonio Alcalde": A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
VEXUS-REA : Evaluation of Ultrasound Parameters of Venous Congestion in Patients in a Medical Intensive Care Unit
Hemodynamic Resuscitation Guided by Non-Invasive Mean Systemic Filling Pressure to Prevent Acute Kidney Injury in Septic Shock: A Randomized Controlled Trial Integrating Renal Doppler Indices
The Impact of Fast Antimicrobial Sensitivity Testing Tools on Stewardship Antibiotic and Clinical Outcome: a Randomized Clinical Trial Within an Adaptive Platform Trial for Patients With Bloodstream Infections
Efficacy, Safety, and Tolerability of Methylprednisolone in Critically Ill Patients With the Hyperinflammatory Phenotype: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase II Trial
Who cites it
2,604 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Effects on mortality of different blood purification techniques in sepsis patients: an umbrella review of systematic reviews and meta-analyses.Renal failure · 2026Pooled it
- Long-term mortality in pediatric sepsis: a systematic review and meta-analysis.Annals of medicine · 2026Pooled it
- High-Flow Nasal Oxygen Versus Conventional Oxygen Therapy and Non-Invasive Ventilation for Acute Respiratory Failure in the Emergency Department: A Systematic Review and Meta-Analysis.Emergency medicine Australasia : EMA · 2026Pooled it
- Hyperoncotic Albumin (20%) Versus Crystalloids for Mortality in Adults with Sepsis and Septic Shock: An Updated Systematic Review and Meta-Analysis.Medical sciences (Basel, Switzerland) · 2026Pooled it
- Guidelines on the Use of Therapeutic Apheresis in Clinical Practice-Evidence-Based Approach From the Writing Committee of the American Society for Apheresis: The Tenth Special Issue.Journal of clinical apheresis · 2026Guideline
- IgM-Enriched Immunoglobulin As Adjunctive Therapy in Adult Sepsis and Septic Shock: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Critical care explorations · 2026Pooled it
- Trial
- Perioperative dexmedetomidine reduces the risk of postoperative complications in high-risk patients undergoing non-cardiac surgery: A randomized controlled trial.Chinese medical journal · 2026Trial
- Effects of a clinical metagenomics intervention on clinical outcomes, healthcare costs, and health-related quality of life in patients with sepsis or septic shock: results of the randomized-controlled DigiSep trial.Intensive care medicine · 2026Trial
- Clinical validation of continuous glucose monitoring in glycemic management of critically ill sepsis patients: A prospective randomized clinical study.The Journal of international medical research · 2026Trial
- Deresuscitation Informed by Ultrasound in Patients With Septic Shock Trial: A Pilot Randomized Controlled Study.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2026Trial
- Efficacy and Safety of Shenfu Injection in Patients with Septic Shock: A Randomized Controlled Open-Label Trial with Network Pharmacology-Based Mechanistic Insights.Chinese journal of integrative medicine · 2026Trial
- HA-330 hemoadsorption in septic shock requiring high-dose norepinephrine: a multicenter randomized controlled trial (CLEANSE).Critical care (London, England) · 2026Trial
- Lactate in acute kidney injury: pathobiology, risk stratification, and clinical interpretation.Renal failure · 2026Review
- Augmented renal clearance: from pathophysiological mechanisms to clinical implications and research perspectives.Renal failure · 2026Review
- Secondary hypoalbuminemia is independently associated with in-hospital mortality in children withAnnals of medicine · 2026Article
- Prognostic value of combined platelet and fibrinogen levels on mortality in pediatric patients with sepsis.Annals of medicine · 2026Article
- Article
- The dual pathogenic role of IL-24 in sepsis: Coupling bacterial dissemination with inflammatory amplification as a therapeutic target.Virulence · 2026Article
- A practical nomogram for predicting multidrug-resistant organism infection in a tertiary county-level hospital to guide antimicrobial therapy.New microbes and new infections · 2026Article
2,544 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
60 authors.
Laura EvansDivision of Pulmonary, Critical Care and Sleep Medicine, University of Washington, Seattle, WA, USA. leevans@uw.edu.ORCID 0000-0002-3176-6493
Andrew RhodesAdult Critical Care, St George's University Hospitals NHS Foundation Trust & St George's University of London, London, UK.
Waleed AlhazzaniDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Massimo AntonelliDipartimento di Scienze dell'Emergenza, Anestesiologiche e della Rianimazione, Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Craig M CoopersmithEmory University School of Medicine, Atlanta, GA, USA.
Craig FrenchWestern Health, Melbourne, Australia.
Flávia R MachadoAnesthesiology, Pain and Intensive Care Department, Federal University of São Paulo, Hospital of São Paulo, São Paulo, Brazil.
Lauralyn McintyreOttawa Hospital, Ottawa, ON, Canada.
Marlies OstermannGuy's & St Thomas' Hospital, London, England, UK.
Hallie C PrescottUniversity of Michigan and VA Center for Clinical Management Research, Ann Arbor, MI, USA.
Christa SchorrCooper Health System, Camden, NJ, USA.
Steven SimpsonUniversity of Kansas Medical Center, Kansas City, KS, USA.
W Joost WiersingaESCMID Study Group for Bloodstream Infections, Endocarditis and Sepsis, Division of Infectious Diseases, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Fayez AlshamsiDepartment of Internal Medicine, College of Medicine and Health Sciences, Emirates University, Al Ain, United Arab Emirates.
Derek C AngusUniversity of Pittsburgh Critical Care Medicine CRISMA Laboratory, Pittsburgh, PA, USA.
Yaseen ArabiIntensive Care Department, Ministry of National Guard Health Affairs, King Abdullah International Medical Research Center, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Kingdom of Saudi Arabia.
Luciano AzevedoSchool of Medicine, University of Sao Paulo, São Paulo, Brazil.
Richard BealeGuy's & St Thomas' Hospital, London, England, UK.
Gregory BeilmanUniversity of Minnesota, Minneapolis, MN, USA.
Emilie Belley-CotePopulation Health Research Institute, Hamilton, ON, Canada.
Lisa BurryMount Sinai Hospital & University of Toronto (Leslie Dan Faculty of Pharmacy), Toronto, ON, Canada.
Maurizio CecconiDepartment of Biomedical Sciences, Humanitas University Pieve Emanuele, Milan, Italy.
John CentofantiDepartment of Anesthesia, McMaster University, Hamilton, ON, Canada.
Angel Coz YatacoLexington Veterans Affairs Medical Center/University of Kentucky College of Medicine, Lexington, KY, USA.
Jan De WaeleGhent University Hospital, Ghent, Belgium.
R Phillip DellingerCooper Health System, Camden, NJ, USA.
Kent DoiThe University of Tokyo, Tokyo, Japan.
Bin DuMedical ICU, Peking Union Medical College Hospital, Beijing, China.
Elisa EstenssoroHospital Interzonal de Agudos San Martin de La Plata, Buenos Aires, Argentina.
Ricard FerrerIntensive Care Department, Vall d'Hebron University Hospital, Vall d'Hebron Institut de Recerca, Barcelona, Spain.
Charles GomersallPrince of Wales Hospital, Hong Kong, China.
Carol HodgsonAustralian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, VIC, Australia.
Morten Hylander MøllerDepartment of Intensive Care 4131, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Theodore IwashynaUniversity of Michigan Health System, Ann Arbor, MI, USA.
Shevin JacobLiverpool School of Tropical Medicine, Liverpool, UK.
Ruth KleinpellVanderbilt University, Nashville, TN, USA.
Michael KlompasDepartment of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Younsuck KohASAN Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Anand KumarUniversity of Manitoba, Winnipeg, MB, Canada.
Arthur KwizeraMakerere University College of Health Sciences, Kampala, Uganda.
Suzana LoboIntensive Care Division, Faculdade de Medicina de São José do Rio Preto, São Paulo, Brazil.
Henry MasurCritical Care Medicine Department, NIH Clinical Center, Bethesda, MD, USA.
Steven McGloughlinAlfred Health, Melbourne, Australia.
Sangeeta MehtaMount Sinai Hospital, Toronto, ON, Canada.
Yatin MehtaMedanta the Medicity, Gurugram, Haryana, India.
Mervyn MerCharlotte Maxeke Johannesburg Academic Hospital and Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Mark NunnallyNew York University School of Medicine, New York, NY, USA.
Simon OczkowskiDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Tiffany OsbornWashington University School of Medicine, St. Louis, MO, USA.
Elizabeth PapathanassoglouFaculty of Nursing, University of Alberta, Edmonton, AB, Canada.
Anders PernerRigshospitalet, Copenhagen, Denmark.
Michael PuskarichUniversity of Minnesota/Hennepin County Medical Center, Minneapolis, MN, USA.
Jason RobertsFaculty of Medicine, University of Queensland Centre for Clinical Research, The University of Queensland, Brisbane, Australia.
William SchweickertUniversity of Pennsylvania, Philadelphia, PA, USA.
Maureen SeckelChristianaCare, Newark, DE, USA.
Jonathan SevranskyEmory University School of Medicine, Atlanta, GA, USA.
Charles L SprungFaculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Tobias WelteMedizinische Hochschule Hannover and German Center of Lung Research (DZL), Hannover, Germany.
Janice ZimmermanWorld Federation of Intensive and Critical Care, Brussels, Belgium.
Mitchell LevyWarren Alpert School of Medicine at Brown University, Providence, Rhode Island & Rhode Island Hospital, Providence, RI, USA.
Funding
No grant is acknowledged in the PubMed record.
Abstract
PubMed holds no abstract for this paper.
Indexed as
SepsisShock, SepticCritical CareHumansAdultsEvidence based medicineGuidelinesSepsisSeptic shock
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
NCT05213923ClinicalTrials.gov
NCT05358912ClinicalTrials.gov
NCT05627817ClinicalTrials.gov
NCT05658692ClinicalTrials.gov
NCT05833412ClinicalTrials.gov
NCT05865743ClinicalTrials.gov
and 25 more above
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.