Evidence map›Paper›PMID 34599677›Full record

ArticleArchives of gynecology and obstetrics2022

Maternal iodine deficiency: a newborns' overweight risk factor? A prospective study.

Yaniv S Ovadia, Shmuel Zangen, Shani R Rosen, Dov Gefel, Shlomo Almashanu, Carlos Benbassat, Shlomo Fytlovich, Dorit Aharoni, Eyal Y Anteby, Simon Shenhav

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In one paragraph

Article in Archives of gynecology and obstetrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Yaniv S OvadiaObstetrics and Gynecology Department, Barzilai University Medical Center Ashkelon, Ashkeon, Israel. yaniv.ovadia@mail.huji.ac.il.ORCID 0000-0001-9846-1515
Shmuel Zangen *Department of Neonatology, Barzilai University Medical Center Ashkelon, Ashkelon, Israel.
Shani R RosenSchool of Nutritional Science, Institute of Biochemistry, Food Science and Nutrition; Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, Israel.
Dov GefelSchool of Nutritional Science, Institute of Biochemistry, Food Science and Nutrition; Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, Israel.
Shlomo AlmashanuNational Newborn Screening Program, Ministry of Health, Tel-Hashomer, Israel.
Carlos BenbassatEndocrine Institute, Shamir Medical Center, Zerifin, Israel.
Shlomo FytlovichLaboratory of Clinical Biochemistry, Barzilai University Medical Center Ashkelon, Ashkelon, Israel.
Dorit AharoniLaboratory of Clinical Biochemistry, Barzilai University Medical Center Ashkelon, Ashkelon, Israel.
Eyal Y AntebyObstetrics and Gynecology Department, Barzilai University Medical Center Ashkelon, Ashkeon, Israel.
Simon Shenhav *Obstetrics and Gynecology Department, Barzilai University Medical Center Ashkelon, Ashkeon, Israel.
Ben-Gurion University of the Negev · ILHebrew University of Jerusalem · ILBarzilai Medical Center · ILIsrael Ministry of Health · ILTel Aviv University · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesChildhood obesity and iodine deficiency are global public health concerns. Whether maternal iodine status mediates overweight in infancy has yet to be explored. We aimed to assess the relationship between maternal iodine status and infant birth weight, including small and large for gestational age (SGA and LGA, respectively).

methodsA prospective study was carried out among 134 mother-infant pairs from Israel. Maternal iodine intake and status were estimated via questionnaire and serum thyroglobulin (Tg), respectively. Estimated iodine intake below the Recommended Daily Allowance for iodine sufficiency in pregnancy (220 μg/d) considered Inadequate. Maternal and neonatal thyroid function and anthropometric measurements, as well as maternal thyroid antibodies were also tested.

resultsAfter screening, 118 participants met the inclusion criteria (distributed trimesters I, II and III: n = 3, n = 21, and n = 94, respectively). There was a negative association of iodine intake with Tg values among the study population. Maternal median Tg value was higher than the sufficiency cutoff (16.5 vs 13 µg/L), indicating insufficient iodine status. No SGA cases were found. Inadequate iodine intake was associated with maternal isolated hypothyroxinemia (OR = 3.4; 95% CI 1.2, 9.9) and higher birthweight (including macrosomia and LGA) rates. A suggestive association of elevated Tg with a greater risk of LGA was observed. Offsprings' birth weight percentiles were associated with Tg values in pregnant women with suggestive sufficient iodine status (n = 62, R

conclusionsIodine status during pregnancy can be associated with newborn anthropometric index. Maternal inadequate iodine intake may alter fetal growth and might increase the risk of LGA among newborns. These initial findings support the need to further study the impact of iodine deficiency on newborns overweight in Israel and elsewhere.

Indexed as

IodinePediatric ObesityChildFemaleHumansInfant, NewbornOverweightPregnancyProspective StudiesRisk FactorsIodineBirth weightIsolated hypothyroxinemiaLarge for gestational ageMaternal iodine intakeThyroglobulin

Identifiers

PMID34599677
OpenAlexW3201931863

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.