Evidence map›Paper›PMID 34599645›Full record

ArticleBasic & clinical pharmacology & toxicology2022

No significant influence of OCT1 genotypes on the pharmacokinetics of morphine in adult surgical patients.

Ida Kuhlmann, Rasmus Hjelmar Petersen, Morten Overgaard, Kenn Dornonville de la Cour, Stine Zwisler, Tore Bjerregaard Stage, Mette Marie Hougaard Christensen, Troels K Bergmann, Per Damkier, Anders Gadegaard Jensen and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Basic & clinical pharmacology & toxicology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Ida KuhlmannClinical Pharmacology, Pharmacy and Environmental Medicine, Department of Public Health, University of Southern Denmark, Odense, Denmark.ORCID https://orcid.org/0000-0003-1727-1264
Rasmus Hjelmar PetersenDepartment of Anesthesiology, Hospital of South West Jutland, Esbjerg, Denmark.
Morten OvergaardDepartment of Anesthesiology, Hospital of South West Jutland, Esbjerg, Denmark.
Kenn Dornonville de la CourDepartment of Anesthesiology, Odense University Hospital, Odense, Denmark.
Stine ZwislerDepartment of Anesthesiology, Odense University Hospital, Odense, Denmark.
Tore Bjerregaard StageClinical Pharmacology, Pharmacy and Environmental Medicine, Department of Public Health, University of Southern Denmark, Odense, Denmark.ORCID https://orcid.org/0000-0002-4698-4389
Mette Marie Hougaard ChristensenDepartment of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark.
Troels K BergmannDepartment of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark.ORCID https://orcid.org/0000-0001-8313-0721
Per DamkierDepartment of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark.ORCID https://orcid.org/0000-0003-0591-7187
Anders Gadegaard JensenDepartment of Anesthesiology, Odense University Hospital, Odense, Denmark.
Flemming NielsenClinical Pharmacology, Pharmacy and Environmental Medicine, Department of Public Health, University of Southern Denmark, Odense, Denmark.
Kim BrøsenClinical Pharmacology, Pharmacy and Environmental Medicine, Department of Public Health, University of Southern Denmark, Odense, Denmark.ORCID https://orcid.org/0000-0001-8444-7835
University of Southern Denmark · DKOdense University Hospital · DKHospital South West Jutland · DK

Funding

Faculty of Health Science, University of Southern DenmarkIndependent Research Fund Denmark 7016-00052BRegion of Southern Denmark 17/15105
6 · The paper itself

Abstract

We investigated the impact of genetic variants in OCT1 (SLC22A1) on morphine, morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G) pharmacokinetics in adult patients scheduled for major surgery. Blood samples were taken before and 5, 10, 15, 30, 45, 60 and 90 min after a bolus of morphine (0.15 mg/kg). Patients were genotyped for the genetic variants (rs12208357, rs34059508, rs72552763 and rs34130495) in OCT1. Eighty-six patients completed the trial. The mean difference (95% confidence interval) for dose adjusted morphine, M3G and M6G AUC was 0.9 (-0.7-2.4), -5.9 (-11.8 to -0.03) and -1.1 (-2.5-0.4) h/L*10

Indexed as

AgedAnalgesics, OpioidArea Under CurveFemaleGenetic VariationGenotypeHumansMaleMiddle AgedMorphineMorphine DerivativesOctamer Transcription Factor-1Postoperative PainTime FactorsAnalgesics, OpioidMorphinemorphine-3-glucuronidemorphine-6-glucuronideMorphine DerivativesOctamer Transcription Factor-1POU2F1 protein, humanM6Gmorphineorganic cation transporter 1pharmacodynamicspharmacokinetics

Identifiers

PMID34599645
PMCPMC9298338
OpenAlexW3204202872

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.