Evidence map›Paper›PMID 34599624›Full record

ArticleClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology2021

Clinical and immunological evaluation of cat-allergic asthmatics living with or without a cat.

Erik R Wambre, Mary Farrington, Veronique Bajzik, Hannah A DeBerg, Marcella Ruddy, Michelle DeVeaux, Pretty Meier, David Robinson, Matt Cantor, Chengrui Huang and 3 more

Open access · hybridAbstract read
In one paragraph

Article in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Trial
  2. Review
  3. Allergy to Cats: Current Perspectives and Therapeutic Options.Clinical and translational allergy · 2026
    Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Clinical and immunological evaluation of cat-allergic asthmatics living with or without a cat.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Erik R WambreBenaroya Research Institute at Virginia Mason Medical Center, Seattle, Washington, USA.ORCID 0000-0002-3628-0011
Mary FarringtonBenaroya Research Institute at Virginia Mason Medical Center, Seattle, Washington, USA.
Veronique BajzikBenaroya Research Institute at Virginia Mason Medical Center, Seattle, Washington, USA.
Hannah A DeBergBenaroya Research Institute at Virginia Mason Medical Center, Seattle, Washington, USA.
Marcella RuddyRegeneron Pharmaceuticals, Tarrytown, New York, USA.
Michelle DeVeauxRegeneron Pharmaceuticals, Tarrytown, New York, USA.
Pretty MeierRegeneron Pharmaceuticals, Tarrytown, New York, USA.
David RobinsonVirginia Mason Medical Center, Seattle, Washington, USA.
Matt CantorKoneksa Health, New York, New York, USA.
Chengrui HuangKoneksa Health, New York, New York, USA.
Jamie M OrengoRegeneron Pharmaceuticals, Tarrytown, New York, USA.
Claire Q WangRegeneron Pharmaceuticals, Tarrytown, New York, USA.
Allen RadinRegeneron Pharmaceuticals, Tarrytown, New York, USA.
Regeneron (United States) · USVirginia Mason Medical Center · US

Funding

Regeneron Pharmaceuticals
6 · The paper itself

Abstract

backgroundCharacterising the clinical and immunological impact of daily cat exposure in cat-allergic subjects with asthma who live with cats (WC) and those who do not (WoC) may provide understanding of the drivers of the allergic response.

methodsClinical and immunological characteristics (skin prick test, spirometry, symptom assessments, immunological markers) were compared between asthmatic subjects WC (n = 10) and WoC (n = 9).

resultsWC subjects had greater use of long-acting beta agonists (p < .05) and high-potency corticosteroids. No differences were observed in lung function, nasal and ocular symptoms, or asthma control between the groups. Cat dander- and Fel d 1-specific IgG

conclusionImmunological differences observed in WC versus WoC did not reflect clinical tolerance with natural cat exposure. The ability to live with a cat despite allergy could be driven by higher preventative medication use. This study may support design of novel therapeutics for allergy management.

Indexed as

AsthmaHypersensitivityAllergensGlycoproteinsHumansImmunoglobulin EAllergensGlycoproteinsImmunoglobulin Ebasophil activationcat allergyFel d 1immunoglobulinsTh2A cells

Identifiers

PMID34599624
PMCPMC9293312
OpenAlexW3203066985

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.