Evidence map›Paper›PMID 34599610›Full record

ArticleActa paediatrica (Oslo, Norway : 1992)2022

Profile of minor neurological findings after perinatal asphyxia.

Anna Kivi, Marjo Metsäranta, Sanna Toiviainen-Salo, Sampsa Vanhatalo, Leena Haataja

Open access · hybridAbstract read
In one paragraph

Article in Acta paediatrica (Oslo, Norway : 1992), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

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  10. Profile of minor neurological findings after perinatal asphyxia.Acta paediatrica (Oslo, Norway : 1992) · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Anna KiviBABA Center, Pediatric Research Center, Department of Pediatrics, Children's Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.ORCID https://orcid.org/0000-0003-3900-6429
Marjo MetsärantaDepartment of Neonatology, Children's Hospital, BABA Center, Pediatric Research Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.ORCID https://orcid.org/0000-0001-6665-9009
Sanna Toiviainen-SaloDepartment of Pediatric Radiology, Radiology, HUS Diagnostic Center, BABA Center, Pediatric Research Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.ORCID https://orcid.org/0000-0003-1176-8165
Sampsa VanhataloDepartment of Clinical Neurophysiology, Children's Hospital, BABA Center, Pediatric Research Center, Neuroscience Center, Helsinki Institute of Life Science, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.ORCID https://orcid.org/0000-0002-9771-7061
Leena HaatajaDepartment of Pediatric Neurology, Children's Hospital, BABA Center, Pediatric Research Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.ORCID https://orcid.org/0000-0002-8057-6194
University of Helsinki · FI

Funding

Helsingin ja Uudenmaan SairaanhoitopiiriLastentautien TutkimussäätiöSigrid Juséliuksen SäätiöSuomalainen Lääkäriseura DuodecimSuomen AivosäätiöSuomen Akatemia 314450Suomen Akatemia 335788
6 · The paper itself

Abstract

aimTo characterise the spectrum of findings in sequential neurological examinations, general movements (GM) assessment and magnetic resonance imaging (MRI) of infants with perinatal asphyxia.

methodsThe prospective cohort study of term infants with perinatal asphyxia treated at Helsinki University Hospital's neonatal units in 2016-2020 used Hammersmith Neonatal Neurological Examination (HNNE) and brain MRI at 2 weeks and Hammersmith Infant Neurological Examination (HINE) and GM assessment at 3 months of age.

resultsAnalysis included 50 infants: 33 displaying perinatal asphyxia without hypoxic-ischaemic encephalopathy (HIE), seven with HIE1 and 10 with HIE2. Of the infants with atypical HNNE findings, 24/25 perinatal asphyxia without HIE cases, 5/6 HIE1 cases and all 10 HIE2 cases showed atypical findings in the HINE. The HINE identified atypical spontaneous movements significantly more often in infants with white matter T2 hyperintensity.

conclusionIn this cohort, most infants with perinatal asphyxia, with or without HIE, presented atypical neurological findings in sequential examinations. The profile of neurological findings for children with perinatal asphyxia without HIE resembled that of children with HIE. White matter T2 hyperintensity was associated with atypical spontaneous movements in the HINE and was a frequent MRI finding also in perinatal asphyxia without HIE.

Indexed as

Asphyxia NeonatorumHypoxia-Ischemia, BrainAsphyxiaChildCohort StudiesFemaleHumansInfantInfant, NewbornPregnancyProspective Studiesgeneral movementshypoxic-ischaemic encephalopathyinfant neurological examinationminor neurological findingperinatal asphyxia

Identifiers

PMID34599610
PMCPMC9299470
OpenAlexW3204955213

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.