Evidence map›Paper›PMID 34599470›Full record

ArticleDrug delivery and translational research2022

Assessment of dermal bioavailability: predicting the input function for topical glucocorticoids using stratum corneum sampling.

Andrea Pensado, Anita McGrogan, K A Jane White, Annette L Bunge, Richard H Guy, M Begoña Delgado-Charro

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug delivery and translational research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Andrea PensadoDepartment of Pharmacy & Pharmacology, University of Bath, Bath, UK.
Anita McGroganDepartment of Pharmacy & Pharmacology, University of Bath, Bath, UK.
K A Jane WhiteDepartment of Mathematical Sciences, University of Bath, Bath, UK.
Annette L BungeChemical and Biological Engineering, Colorado School of Mines, Golden, CO, USA.
Richard H GuyDepartment of Pharmacy & Pharmacology, University of Bath, Bath, UK.
M Begoña Delgado-CharroDepartment of Pharmacy & Pharmacology, University of Bath, Bath, UK. b.delgado-charro@bath.ac.uk.ORCID 0000-0002-2233-7654
University of Bath · GBColorado School of Mines · USOkinawa Institute of Science and Technology Graduate University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Predicting the dermal bioavailability of topically delivered drugs is challenging. In this work, minimally invasive stratum corneum (SC) sampling was used to quantify the delivery of betamethasone valerate (BMV) into the viable skin. Betnovate® cream (0.1% w/w BMV) was applied at three doses (2, 5, and 10 mg cm

Indexed as

GlucocorticoidsSkin AbsorptionBetamethasone ValerateEpidermisHumansSkinBetamethasone ValerateGlucocorticoidsBetamethasone valerateSkin blanchingStratum corneum samplingTopical bioavailabilityTopical corticosteroids

Identifiers

PMID34599470
PMCPMC8888398
OpenAlexW3202031840

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.